UNASSIGNED: Studies examining respiration and EEG-recorded brain activity in human neonates between 28 and 42 weeks postmenstrual age were included. Two reviewers independently screened all records and included studies were assessed using the Joanna Briggs Institute Critical Appraisal Tool. The protocol was registered in PROSPERO (CRD42022339873).
UNASSIGNED: We identified 14 studies with a total of 534 infants. Nine articles assessed EEG changes in relation to apnoea, one assessed hiccups, and four investigated the effect of respiratory stimulants. The relationship between neonatal apnoea and EEG changes was inconsistent; EEG suppression and decreased amplitude and frequency were observed during some, but not all, apnoeas. Respiratory stimulants increased EEG continuity compared with before use.
UNASSIGNED: Current studies in this area are constrained by small sample sizes. Diverse exposure definitions and outcome measures impact inference.
UNASSIGNED: This review highlights the need for further work; understanding the relationship between respiration and the developing brain is key to mitigating the long-term effects of apnoea.
■研究检查了月经后28至42周龄的人类新生儿的呼吸和脑电图记录的大脑活动。两名评审员独立筛选了所有记录,并使用JoannaBriggs研究所关键评估工具对纳入的研究进行了评估。该方案在PROSPERO(CRD42022339873)中注册。
■我们确定了14项研究,共534名婴儿。九篇文章评估了与呼吸暂停相关的脑电图变化,一个评估打嗝,四个人研究了呼吸兴奋剂的作用。新生儿呼吸暂停与脑电图改变的关系不一致;在某些情况下观察到脑电图抑制和振幅和频率降低,但不是全部,apnoeas.与使用前相比,呼吸兴奋剂增加了EEG的连续性。
■该领域的当前研究受到样本量小的限制。不同的暴露定义和结果度量影响推断。
■这篇综述强调了进一步工作的必要性;了解呼吸与发育中的大脑之间的关系是减轻呼吸暂停长期影响的关键。