PDF(Pubmed)
Abstract：
Paraneoplastic syndromes are rare and diverse conditions caused by either an abnormal chemical signaling molecule produced by tumor cells or a body\'s immune response against the tumor itself. These syndromes can manifest in a variable, multisystemic and often nonspecific manner posing a diagnostic challenge. We report the case of an 81-year-old woman who exhibited severe hypokalemia, metabolic alkalosis, and worsening hyperglycemia. The investigation was consistent with adrenocorticotropin (ACTH)-dependent Cushing\'s syndrome and, eventually, the patient was diagnosed with stage IV primary small-cell lung cancer (SCLC). SCLC is known to be associated with paraneoplastic syndromes, including Cushing\'s syndrome caused by ectopic adrenocorticotropin (ACTH) secretion. Despite being associated with very poor outcomes, managing these syndromes can be challenging and may hold prognostic significance.
摘要：
副肿瘤综合征是由肿瘤细胞产生的异常化学信号分子或机体对肿瘤本身的免疫反应引起的罕见且多样的疾病。这些综合症可以表现在一个变量中，多系统且通常是非特异性的方式构成了诊断挑战。我们报告了一个81岁的女性，她表现出严重的低钾血症，代谢性碱中毒，和恶化的高血糖症。该研究与促肾上腺皮质激素（ACTH）依赖性库欣综合征一致，最终,患者被诊断为IV期原发性小细胞肺癌(SCLC).已知SCLC与副肿瘤综合征有关，包括由异位促肾上腺皮质激素（ACTH）分泌引起的库欣综合征。尽管与非常糟糕的结果有关，管理这些综合征可能具有挑战性,并且可能具有预后意义.
