PDF(Pubmed)
Abstract：
UNASSIGNED: Neonatal sepsis remains a major cause of morbidity and mortality. Therefore, early detection and initiation of appropriate empirical antibiotic therapy are crucial.
UNASSIGNED: The aim of this study was to describe the antibiogram of the neonatal intensive care unit at Grey\'s Hospital, a tertiary hospital in KwaZulu-Natal.
UNASSIGNED: This was a retrospective descriptive study, reviewing positive cultures from Grey\'s Hospital tertiary neonatal intensive care unit (NICU) in KwaZulu-Natal, South Africa for a 3-year period (01 January 2017 to 31 December 2019). All positive cultures from all sites were included.
UNASSIGNED: There were 1314 positive organisms cultured. Late-onset sepsis (89.3%) predominated over early-onset sepsis (10.7%). Blood was the source for 55.2% (725/1314) of positive cultures. Of the 1314 organisms cultured, 53.7% (706/1314) were Gram-positive, 45.7% (601/1314) were Gram-negative and 0.5% (7/1314) were Candida species. Klebsiella pneumoniae, 23.5% (313/1314) was the most frequent Gram-negative organism. It was noted to have high resistance to the unit\'s first-line antibiotic regimens; 99% were resistant to ampicillin and 92% resistant to gentamicin.
UNASSIGNED: Blood cultures yielded most positive results with a predominance of Gram-positive organisms and late-onset sepsis. A significant proportion of the cultured organisms were resistant to the first-line antimicrobials utilised in the unit, ampicillin and gentamicin.
UNASSIGNED: Ongoing surveillance on positive cultures is recommended to assess the effectiveness of the unit\'s current empirical antimicrobial guideline.
UNASSIGNED: The aim of this study was to describe the antibiogram of the neonatal intensive care unit at Grey\'s Hospital, a tertiary hospital in KwaZulu-Natal.
UNASSIGNED: This was a retrospective descriptive study, reviewing positive cultures from Grey\'s Hospital tertiary neonatal intensive care unit (NICU) in KwaZulu-Natal, South Africa for a 3-year period (01 January 2017 to 31 December 2019). All positive cultures from all sites were included.
UNASSIGNED: There were 1314 positive organisms cultured. Late-onset sepsis (89.3%) predominated over early-onset sepsis (10.7%). Blood was the source for 55.2% (725/1314) of positive cultures. Of the 1314 organisms cultured, 53.7% (706/1314) were Gram-positive, 45.7% (601/1314) were Gram-negative and 0.5% (7/1314) were Candida species. Klebsiella pneumoniae, 23.5% (313/1314) was the most frequent Gram-negative organism. It was noted to have high resistance to the unit\'s first-line antibiotic regimens; 99% were resistant to ampicillin and 92% resistant to gentamicin.
UNASSIGNED: Blood cultures yielded most positive results with a predominance of Gram-positive organisms and late-onset sepsis. A significant proportion of the cultured organisms were resistant to the first-line antimicrobials utilised in the unit, ampicillin and gentamicin.
UNASSIGNED: Ongoing surveillance on positive cultures is recommended to assess the effectiveness of the unit\'s current empirical antimicrobial guideline.
摘要：
■新生儿败血症仍然是发病率和死亡率的主要原因。因此,早期发现和开始适当的经验性抗生素治疗至关重要.
■这项研究的目的是描述格雷医院新生儿重症监护病房的抗菌图，夸祖鲁-纳塔尔省的一家三级医院.
■这是一项回顾性的描述性研究，回顾来自夸祖鲁-纳塔尔省格雷医院三级新生儿重症监护病房（NICU）的积极文化，南非为期3年（2017年1月1日至2019年12月31日）。包括来自所有位点的所有阳性培养物。
■培养了1314个阳性生物体。晚发性败血症（89.3％）比早发性败血症（10.7％）占优势。血液是55.2％（725/1314）阳性培养物的来源。在培养的1314种生物中，53.7%（706/1314）为革兰氏阳性，45.7%(601/1314)为革兰氏阴性,0.5%(7/1314)为念珠菌属。肺炎克雷伯菌,23.5%(313/1314)是最常见的革兰氏阴性菌。注意到对该单位的一线抗生素方案具有高抗性；99%对氨苄西林耐药，92%对庆大霉素耐药。
■血液培养产生最积极的结果，主要是革兰氏阳性生物体和迟发性败血症。相当比例的培养生物对单位中使用的一线抗菌药物具有抗性，氨苄青霉素和庆大霉素。
■建议对阳性培养物进行持续监测，以评估该单位当前经验抗菌指南的有效性。
■这项研究的目的是描述格雷医院新生儿重症监护病房的抗菌图，夸祖鲁-纳塔尔省的一家三级医院.
■这是一项回顾性的描述性研究，回顾来自夸祖鲁-纳塔尔省格雷医院三级新生儿重症监护病房（NICU）的积极文化，南非为期3年（2017年1月1日至2019年12月31日）。包括来自所有位点的所有阳性培养物。
■培养了1314个阳性生物体。晚发性败血症（89.3％）比早发性败血症（10.7％）占优势。血液是55.2％（725/1314）阳性培养物的来源。在培养的1314种生物中，53.7%（706/1314）为革兰氏阳性，45.7%(601/1314)为革兰氏阴性,0.5%(7/1314)为念珠菌属。肺炎克雷伯菌,23.5%(313/1314)是最常见的革兰氏阴性菌。注意到对该单位的一线抗生素方案具有高抗性；99%对氨苄西林耐药，92%对庆大霉素耐药。
■血液培养产生最积极的结果，主要是革兰氏阳性生物体和迟发性败血症。相当比例的培养生物对单位中使用的一线抗菌药物具有抗性，氨苄青霉素和庆大霉素。
■建议对阳性培养物进行持续监测，以评估该单位当前经验抗菌指南的有效性。
