Abstract：
OBJECTIVE: This study is aim to explore the causal relationship between anxiety, depression, neuroticism, and Meniere\'s disease (MD).
METHODS: Two-sample bidirectional Mendelian randomization (MR) analyses.
METHODS: IEU, FinnGen, CTG, and UKB databases.
METHODS: The genome-wide association studies data for anxiety, depression, neuroticism, and MD involved over 357,957 participants. MR was performed to explore relationships between anxiety, depression, neuroticism, and MD. Sensitivity analyses were performed to assess the robustness of the MR results. Reverse MR was used to exclude the possibility of reverse causality. Finally, multivariate MR was performed to explore the collinear relationships between neuroticism subclusters.
RESULTS: MR results showed that anxiety and depression are not causes of MD, nor does MD cause anxiety and depression. Elevated neuroticism sum score is a cause of anxiety, depression, and MD, but MD does not lead to an increase in the level of neuroticism sum score. Further analysis showed that the 5 subclusters of neuroticism often feel lonely, mood often goes up and down, often feel fed-up, feelings easily hurt, and sensitivity to environmental stress and adversity are causes of MD. Multivariate MR analysis results suggested that the 5 neuroticism subclusters have a collinear relationship.
CONCLUSIONS: Anxiety and depression are not causative factors of MD, and vice versa. Elevated neuroticism levels serve as a shared causative factor for anxiety, depression, and MD. Identification and effective management of neuroticism is a potential target for preventing and treating MD.
METHODS: Two-sample bidirectional Mendelian randomization (MR) analyses.
METHODS: IEU, FinnGen, CTG, and UKB databases.
METHODS: The genome-wide association studies data for anxiety, depression, neuroticism, and MD involved over 357,957 participants. MR was performed to explore relationships between anxiety, depression, neuroticism, and MD. Sensitivity analyses were performed to assess the robustness of the MR results. Reverse MR was used to exclude the possibility of reverse causality. Finally, multivariate MR was performed to explore the collinear relationships between neuroticism subclusters.
RESULTS: MR results showed that anxiety and depression are not causes of MD, nor does MD cause anxiety and depression. Elevated neuroticism sum score is a cause of anxiety, depression, and MD, but MD does not lead to an increase in the level of neuroticism sum score. Further analysis showed that the 5 subclusters of neuroticism often feel lonely, mood often goes up and down, often feel fed-up, feelings easily hurt, and sensitivity to environmental stress and adversity are causes of MD. Multivariate MR analysis results suggested that the 5 neuroticism subclusters have a collinear relationship.
CONCLUSIONS: Anxiety and depression are not causative factors of MD, and vice versa. Elevated neuroticism levels serve as a shared causative factor for anxiety, depression, and MD. Identification and effective management of neuroticism is a potential target for preventing and treating MD.
摘要：
目的：本研究旨在探讨焦虑之间的因果关系，抑郁症,神经质,和梅尼埃病（MD）。
方法：双样本双向孟德尔随机化（MR）分析。
方法：IEU，FinnGen,CTG,UKB数据库。
方法：全基因组关联研究焦虑的数据，抑郁症,神经质,和MD涉及超过357,957名参与者。进行MR以探索焦虑之间的关系，抑郁症,神经质,和MD。进行敏感性分析以评估MR结果的稳健性。反向MR用于排除反向因果关系的可能性。最后,进行多变量MR以探索神经质亚簇之间的共线性关系。
结果：MR结果显示焦虑和抑郁不是MD的原因，MD也不会引起焦虑和抑郁。神经质总分升高是焦虑的一个原因，抑郁症,和MD,但MD不会导致神经质总分水平的增加。进一步的分析表明，神经质的5个亚簇经常感到孤独，情绪经常起伏不定，经常感到厌倦，感情很容易受到伤害,对环境压力和逆境的敏感性是MD的原因。多变量MR分析结果表明，5个神经质亚簇具有共线性关系。
结论：焦虑和抑郁不是MD的致病因素，反之亦然。神经质水平升高是焦虑的共同原因，抑郁症,和MD。神经质的识别和有效管理是预防和治疗MD的潜在目标。
方法：双样本双向孟德尔随机化（MR）分析。
方法：IEU，FinnGen,CTG,UKB数据库。
方法：全基因组关联研究焦虑的数据，抑郁症,神经质,和MD涉及超过357,957名参与者。进行MR以探索焦虑之间的关系，抑郁症,神经质,和MD。进行敏感性分析以评估MR结果的稳健性。反向MR用于排除反向因果关系的可能性。最后,进行多变量MR以探索神经质亚簇之间的共线性关系。
结果：MR结果显示焦虑和抑郁不是MD的原因，MD也不会引起焦虑和抑郁。神经质总分升高是焦虑的一个原因，抑郁症,和MD,但MD不会导致神经质总分水平的增加。进一步的分析表明，神经质的5个亚簇经常感到孤独，情绪经常起伏不定，经常感到厌倦，感情很容易受到伤害,对环境压力和逆境的敏感性是MD的原因。多变量MR分析结果表明，5个神经质亚簇具有共线性关系。
结论：焦虑和抑郁不是MD的致病因素，反之亦然。神经质水平升高是焦虑的共同原因，抑郁症,和MD。神经质的识别和有效管理是预防和治疗MD的潜在目标。
