关键词: cancer drug delivery ferroelectric materials nanocarrier piezoelectric materials polarization pyroelectric materials

Mesh : Drug Delivery Systems Neoplasms / drug therapy

来  源:   DOI:10.1016/j.drudis.2023.103862

Abstract:
Piezoelectric materials, capable of converting mechanical energy into electrical energy and vice versa, have emerged as promising candidates for designing intelligent drug delivery vehicles. Leveraging their inherent electrical properties, these materials respond to external stimuli, such as mechanical forces and electrical signals, to control drug release. By integrating piezoelectric materials into drug delivery systems, we can achieve exacting control over drug-release mechanisms. Piezoelectric materials hold enormous promise as smart delivery vehicles in cancer treatment, responding to mechanical and electrical cues, enabling site-specific drug release, reducing systemic toxicity and enhancing therapeutic effectiveness. Further advancements in the field are expected to lead to innovative piezoelectric-based systems that can revolutionize cancer treatment strategies, as explored in this review article.
摘要:
压电材料,能够将机械能转化为电能,反之亦然,已经成为设计智能药物输送车辆的有希望的候选人。利用它们固有的电性能,这些材料对外部刺激的反应,如机械力和电信号,控制药物释放。通过将压电材料集成到药物输送系统中,我们可以实现对药物释放机制的严格控制。压电材料作为癌症治疗中的智能运载工具有着巨大的前景,响应机械和电气线索,使特定部位的药物释放,减少全身毒性和提高治疗效果。该领域的进一步进步有望导致创新的基于压电的系统,可以彻底改变癌症治疗策略,正如这篇评论文章所探讨的那样。
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