Abstract：
The long-term use of pediatric medications can lead to discoloration of dental restorations, which affects their durability and longevity. The present in vitro study evaluated the effects of commonly used pediatric medications on the color stability of a conventional and a bulk-fill composite resin. For this study, 80 disc-shaped specimens of each composite were prepared in molds with a diameter of 6 mm and thicknesses of 2 or 4 mm (n = 40 per thickness per material). A spectrophotometer was used to evaluate the baseline color of the specimens in the International Commission on Illumination L*a*b* color space. Each specimen was immersed separately in a container holding 1 of 8 liquid medications (n = 5 per thickness per medication): amoxicillin/clavulanate, clarithromycin, cephalexin, acetaminophen, ibuprofen, levetiracetam, multivitamin, or albuterol. After the container was shaken for 2 minutes, the specimen was removed from the medication and stored in artificial saliva. The cycle was repeated every 8 hours for 1 week. The color measurements were repeated after 1 week of immersion cycles, and the overall color change (ΔE*) was calculated; a value of ΔE* > 3.3 was considered clinically perceptible. The data were analyzed with 1-way and 2-way analyses of variance as well as the Levene test and Games-Howell post hoc test (P < 0.05). All specimens displayed clinically perceptible color changes after exposure to medications commonly used by children. The mean color change in the 4-mm bulk-fill composite resin group was significantly greater than that in all other groups (P < 0.05). However, there was no significant difference in color change based on the immersion drug for either of the composites (P > 0.05). The study findings show that exposure of composite resin to certain commonly used pediatric drugs causes color changes that are clinically perceptible.
摘要：
长期使用儿科药物会导致牙齿修复物变色，这影响了它们的耐用性和寿命。本体外研究评估了常用儿科药物对常规和散装复合树脂颜色稳定性的影响。对于这项研究，在直径为6mm且厚度为2或4mm(每种材料的厚度n=40)的模具中制备每种复合材料的80个圆盘形试样。在国际照明委员会L*a*b*颜色空间中,使用分光光度计评估样本的基线颜色。将每个样本分别浸入装有8种液体药物中的1种的容器中（每种药物的厚度n=5）：阿莫西林/克拉维酸，克拉霉素,头孢氨苄,对乙酰氨基酚,布洛芬,左乙拉西坦,多种维生素，或者沙丁胺醇.将容器摇动2分钟后，将样本从药物中取出并储存在人工唾液中。该循环每8小时重复一次,持续1周。在1周的浸没循环后重复颜色测量,并计算总体颜色变化(ΔE*);ΔE*>3.3的值被认为是临床上可感知的。采用单向和双向方差分析以及Levene检验和Games-Howell事后检验对数据进行分析(P<0.05)。暴露于儿童常用药物后，所有标本均显示出临床上可感知的颜色变化。4-mm填充复合树脂组的平均颜色变化显着大于所有其他组（P<0.05）。然而,两种复合材料的颜色变化均无明显差异（P>0.05）。研究结果表明，复合树脂暴露于某些常用的儿科药物会导致临床上可感知的颜色变化。
