Psoriasis is an autoimmune skin disease that may also affect the joints. Factors leading to the progression of psoriasis to psoriatic arthritis are still a mystery despite an increasing number of animal studies and real-life data. HMGB1 is a nuclear protein that leads to an increase in molecules that increase inflammation (TNF-α, IL-1 and IL-6) in the body. Until now, there was no report about the relationship between psoriatic arthritis and serum HMGB1 levels. Our study aimed to find any difference in HMGB1 levels between healthy and psoriatic patients. Psoriatic arthritis patients had higher levels of serum HMGB1 than patients with psoriasis. Also, HMGB1 levels were correlated with the severity of skin involvement. Our results showed that serum HMGB1 may indicate a high risk for developing psoriasis that involves the joints. Therefore the HMGB1 level in psoriasis patients can potentially serve as a predictor associated with disease severity and the risk of developing psoriatic arthritis.
银屑病是一种自身免疫性皮肤病,也可能影响关节。尽管越来越多的动物研究和现实数据,导致牛皮癣进展为银屑病关节炎的因素仍然是一个谜。HMGB1是一种核蛋白,可导致增加炎症的分子增加(TNF-α,IL-1和IL-6)在体内。直到现在,没有关于银屑病关节炎与血清HMGB1水平之间关系的报道。我们的研究旨在发现健康和银屑病患者之间HMGB1水平的任何差异。银屑病关节炎患者血清HMGB1水平高于银屑病患者。此外,HMGB1水平与皮肤受累的严重程度相关。我们的结果表明,血清HMGB1可能表明发生涉及关节的牛皮癣的高风险。因此,牛皮癣患者中的HMGB1水平可以潜在地用作与疾病严重程度和发展牛皮癣性关节炎的风险相关的预测因子。