Abstract：
Background/aim: Psoriasis is a chronic autoimmune disease that predominantly affects the skin and musculoskeletal system. We hypothesized that HMGB1, an inflammatory nuclear protein, may play a role in the musculoskeletal involvement of psoriasis. Methods: Forty patients with psoriasis and 45 with psoriatic arthritis were involved in the study; the results were compared with 22 healthy controls. Serum HMGB1 levels were evaluated from peripheral blood samples. Results: Serum HMGB1 levels were found to be significantly higher in patients with psoriasis regardless of joint involvement (p < 0.001). Also, HMGB1 levels were correlated with the extent of psoriasis. Conclusion: Serum HMGB1 levels may contribute to the progression of psoriasis to psoriatic arthritis and correlate with the severity of skin involvement.
Psoriasis is an autoimmune skin disease that may also affect the joints. Factors leading to the progression of psoriasis to psoriatic arthritis are still a mystery despite an increasing number of animal studies and real-life data. HMGB1 is a nuclear protein that leads to an increase in molecules that increase inflammation (TNF-α, IL-1 and IL-6) in the body. Until now, there was no report about the relationship between psoriatic arthritis and serum HMGB1 levels. Our study aimed to find any difference in HMGB1 levels between healthy and psoriatic patients. Psoriatic arthritis patients had higher levels of serum HMGB1 than patients with psoriasis. Also, HMGB1 levels were correlated with the severity of skin involvement. Our results showed that serum HMGB1 may indicate a high risk for developing psoriasis that involves the joints. Therefore the HMGB1 level in psoriasis patients can potentially serve as a predictor associated with disease severity and the risk of developing psoriatic arthritis.
Psoriasis is an autoimmune skin disease that may also affect the joints. Factors leading to the progression of psoriasis to psoriatic arthritis are still a mystery despite an increasing number of animal studies and real-life data. HMGB1 is a nuclear protein that leads to an increase in molecules that increase inflammation (TNF-α, IL-1 and IL-6) in the body. Until now, there was no report about the relationship between psoriatic arthritis and serum HMGB1 levels. Our study aimed to find any difference in HMGB1 levels between healthy and psoriatic patients. Psoriatic arthritis patients had higher levels of serum HMGB1 than patients with psoriasis. Also, HMGB1 levels were correlated with the severity of skin involvement. Our results showed that serum HMGB1 may indicate a high risk for developing psoriasis that involves the joints. Therefore the HMGB1 level in psoriasis patients can potentially serve as a predictor associated with disease severity and the risk of developing psoriatic arthritis.
摘要：
背景/目的：银屑病是一种主要影响皮肤和肌肉骨骼系统的慢性自身免疫性疾病。我们假设HMGB1，一种炎性核蛋白，可能在牛皮癣的肌肉骨骼受累中起作用。方法:40例银屑病患者和45例银屑病关节炎患者纳入研究,并与22例健康对照者进行比较。从外周血样品评估血清HMGB1水平。结果：无论关节受累，银屑病患者的血清HMGB1水平均明显升高（p<0.001）。此外，HMGB1水平与银屑病程度相关。结论:血清HMGB1水平可能参与银屑病向银屑病关节炎的进展,并与皮肤受累程度相关。
银屑病是一种自身免疫性皮肤病，也可能影响关节。尽管越来越多的动物研究和现实数据，导致牛皮癣进展为银屑病关节炎的因素仍然是一个谜。HMGB1是一种核蛋白，可导致增加炎症的分子增加（TNF-α，IL-1和IL-6）在体内。直到现在,没有关于银屑病关节炎与血清HMGB1水平之间关系的报道。我们的研究旨在发现健康和银屑病患者之间HMGB1水平的任何差异。银屑病关节炎患者血清HMGB1水平高于银屑病患者。此外，HMGB1水平与皮肤受累的严重程度相关。我们的结果表明，血清HMGB1可能表明发生涉及关节的牛皮癣的高风险。因此,牛皮癣患者中的HMGB1水平可以潜在地用作与疾病严重程度和发展牛皮癣性关节炎的风险相关的预测因子。
银屑病是一种自身免疫性皮肤病，也可能影响关节。尽管越来越多的动物研究和现实数据，导致牛皮癣进展为银屑病关节炎的因素仍然是一个谜。HMGB1是一种核蛋白，可导致增加炎症的分子增加（TNF-α，IL-1和IL-6）在体内。直到现在,没有关于银屑病关节炎与血清HMGB1水平之间关系的报道。我们的研究旨在发现健康和银屑病患者之间HMGB1水平的任何差异。银屑病关节炎患者血清HMGB1水平高于银屑病患者。此外，HMGB1水平与皮肤受累的严重程度相关。我们的结果表明，血清HMGB1可能表明发生涉及关节的牛皮癣的高风险。因此,牛皮癣患者中的HMGB1水平可以潜在地用作与疾病严重程度和发展牛皮癣性关节炎的风险相关的预测因子。
