Abstract：
Soft bioelectronic technologies for neuroengineering have shown remarkable progress, which include novel soft material technologies and device design strategies. Such technological advances that are initiated from fundamental brain science are applied to clinical neuroscience and provided meaningful promises for significant improvement in the diagnosis efficiency and therapeutic efficacy of various brain diseases recently. System-level integration strategies in consideration of specific disease circumstances can enhance treatment effects further. Here, recent advances in soft implantable bioelectronics for neuroengineering, focusing on materials and device designs optimized for the treatment of intracranial disease environments, are reviewed. Various types of soft bioelectronics for neuroengineering are categorized and exemplified first, and then details for the sensing and stimulating device components are explained. Next, application examples of soft implantable bioelectronics to clinical neuroscience, particularly focusing on the treatment of brain tumor and epilepsy are reviewed. Finally, an ideal system of soft intracranial bioelectronics such as closed-loop-type fully-integrated systems is presented, and the remaining challenges for their clinical translation are discussed.
摘要：
神经工程的软生物电子技术已经取得了显著的进展,其中包括新颖的软材料技术和设备设计策略。从基础脑科学开始的这种技术进步最近已应用于临床神经科学，并为各种脑疾病的诊断效率和治疗效果的显着改善提供了有意义的承诺。考虑到特定疾病情况的系统级整合策略可以进一步提高治疗效果。这里,我们回顾了用于神经工程的软可植入生物电子学的最新进展，专注于为治疗颅内疾病环境而优化的材料和设备设计。我们首先分类并举例说明用于神经工程的各种类型的软生物电子学，然后解释传感和刺激设备组件的细节。接下来,我们回顾了软植入式生物电子学在临床神经科学中的应用实例，特别关注脑肿瘤和癫痫的治疗。最后,我们提出了一个理想的软颅内生物电子学系统，如闭环型全集成系统，并讨论其临床翻译的剩余挑战。本文受版权保护。保留所有权利。
