Abstract：
Nanotechnological interventions for cancer immunotherapy are a rapidly evolving paradigm with immense potential. Self-assembled nanobiomaterials present safer alternatives to their nondegradable counterparts and pose better functionalities in terms of controlled drug delivery and phototherapy to activate immunogenic cell death. In this Review, we discuss several classes of self-assembled nanobiomaterials based on polymers, lipids, peptides, hydrogel, metal organic frameworks, and covalent-organic frameworks with the ability to activate systemic immune response and convert a \"cold\" immunosuppressive tumor mass to a \"hot\" antitumor immune cell rich microenvironment. The unique aspects of these materials are underpinned, and their mechanisms of combinatorial immunotherapeutic action are discussed. Future challenges associated with their clinical translation are also highlighted.
摘要：
用于癌症免疫疗法的纳米技术干预是具有巨大潜力的快速发展的范例。自组装纳米材料为其不可降解的对应物提供了更安全的替代品，并且在受控药物递送和光疗方面具有更好的功能以激活免疫原性细胞死亡。在这篇评论中,我们讨论了几类基于聚合物的自组装纳米材料，脂质，肽，水凝胶，金属有机框架，和共价有机框架，具有激活全身免疫反应并将“冷”免疫抑制肿瘤块转化为“热”抗肿瘤免疫细胞丰富的微环境的能力。这些材料的独特方面得到了支撑，并讨论了它们的组合免疫治疗作用机制。还强调了与他们的临床翻译相关的未来挑战。
