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Abstract：
Successful occupancy of a given niche requires the colonising bacteria to interact extensively with the biotic and abiotic environment, including other resident microbes. Bacteria have evolved a range of protein secretion machines for this purpose with eleven such systems identified to date. The type VIIb secretion system (T7SSb) is utilised by Bacillota to secrete a range of protein substrates, including antibacterial toxins targeting closely related strains, and the system as a whole has been implicated in a range of activities such as iron acquisition, intercellular signalling, host colonisation and virulence. This review covers the components and secretion mechanism of the T7SSb, the substrates of these systems and their roles in Gram-positive bacteria, with a focus on interbacterial competition.
摘要：
成功占据给定的生态位需要定殖细菌与生物和非生物环境广泛相互作用，包括其他常驻微生物。为此，细菌已经进化出一系列蛋白质分泌机器，迄今为止已经确定了11个这样的系统。芽孢杆菌利用VIIb型分泌系统（T7SSb）分泌一系列蛋白质底物，包括针对密切相关菌株的抗菌毒素，整个系统参与了一系列活动，例如铁的获取，细胞间信号，宿主定殖和毒力。本文综述了T7SSb的组成和分泌机制。这些系统的底物及其在革兰氏阳性细菌中的作用，专注于细菌间的竞争。
