PDF(Pubmed)
Abstract：
UNASSIGNED: The advanced glycation end product (AGE) is produced from the nonenzymatic reaction between glucose and macromolecules by aging. Accumulation of AGE causes functional and structural changes in body proteins that lead to impairment of tissue protein functions. We aimed to validate AGE measurement by skin autofluorescence (SAF) in diabetes mellitus (DM) compared to the nondiabetes population.
UNASSIGNED: We searched the PubMed, Cochrane, and Scopus databases from their inception till September 18, 2022, for casecontrol studies measuring AGE by SAF. Nonhuman studies, as well as review articles, study proposals, editorials, case reports, or congress posters, were excluded. We used a random effects model to assess the standard mean difference (MD) of age, body mass index (BMI), HbA1c, and SAF between diabetes and nondiabetes individuals.
UNASSIGNED: Higher SAF in DM patients indicated more accumulation of AGE compared with the nondiabetic population. Furthermore, HbA1c was considerably higher in DM patients. The MD of age, male gender, and BMI were significantly different between the DM individuals, compared with nondiabetic subjects, which can lead to altered SAF level and AGE production. There was a remarkable heterogeneity between diabetes and nondiabetes when measuring age, gender, and BMI, as well as HbA1c and SAF level.
UNASSIGNED: This study could not confirm the validity of SAF as a surrogate marker in diabetes patients. Interestingly, metabolic load and high BMI can increase SAF, considerably. Altogether, SAF could be helpful in the future as a marker for metabolic syndrome or diabetes.
UNASSIGNED: We searched the PubMed, Cochrane, and Scopus databases from their inception till September 18, 2022, for casecontrol studies measuring AGE by SAF. Nonhuman studies, as well as review articles, study proposals, editorials, case reports, or congress posters, were excluded. We used a random effects model to assess the standard mean difference (MD) of age, body mass index (BMI), HbA1c, and SAF between diabetes and nondiabetes individuals.
UNASSIGNED: Higher SAF in DM patients indicated more accumulation of AGE compared with the nondiabetic population. Furthermore, HbA1c was considerably higher in DM patients. The MD of age, male gender, and BMI were significantly different between the DM individuals, compared with nondiabetic subjects, which can lead to altered SAF level and AGE production. There was a remarkable heterogeneity between diabetes and nondiabetes when measuring age, gender, and BMI, as well as HbA1c and SAF level.
UNASSIGNED: This study could not confirm the validity of SAF as a surrogate marker in diabetes patients. Interestingly, metabolic load and high BMI can increase SAF, considerably. Altogether, SAF could be helpful in the future as a marker for metabolic syndrome or diabetes.
摘要：
■晚期糖基化终产物（AGE）是由葡萄糖和大分子之间的非酶促反应通过衰老产生的。AGE的积累引起身体蛋白质的功能和结构变化，导致组织蛋白质功能受损。我们旨在与非糖尿病人群相比，通过皮肤自发荧光（SAF）验证糖尿病（DM）中的AGE测量。
■我们搜索了PubMed，科克伦,和Scopus数据库从成立到2022年9月18日，用于SAF测量AGE的病例控制研究。非人类研究,以及评论文章，研究提案,社论,病例报告,或国会海报，被排除在外。我们使用随机效应模型来评估年龄的标准平均差(MD)，体重指数（BMI），HbA1c,糖尿病和非糖尿病个体之间的SAF。
■与非糖尿病人群相比，DM患者的SAF较高表明AGE的积累更多。此外，糖尿病患者的HbA1c明显升高。年龄的MD，男性,和BMI在DM个体之间有显著差异，与非糖尿病受试者相比，这可能导致SAF水平和AGE产量的变化。在测量年龄时，糖尿病和非糖尿病之间存在显著的异质性，性别,BMI,以及HbA1c和SAF水平。
■本研究无法证实SAF作为糖尿病患者替代指标的有效性。有趣的是,代谢负荷和高BMI可增加SAF，相当。总之,SAF可能在未来作为代谢综合征或糖尿病的标志物有所帮助。
■我们搜索了PubMed，科克伦,和Scopus数据库从成立到2022年9月18日，用于SAF测量AGE的病例控制研究。非人类研究,以及评论文章，研究提案,社论,病例报告,或国会海报，被排除在外。我们使用随机效应模型来评估年龄的标准平均差(MD)，体重指数（BMI），HbA1c,糖尿病和非糖尿病个体之间的SAF。
■与非糖尿病人群相比，DM患者的SAF较高表明AGE的积累更多。此外，糖尿病患者的HbA1c明显升高。年龄的MD，男性,和BMI在DM个体之间有显著差异，与非糖尿病受试者相比，这可能导致SAF水平和AGE产量的变化。在测量年龄时，糖尿病和非糖尿病之间存在显著的异质性，性别,BMI,以及HbA1c和SAF水平。
■本研究无法证实SAF作为糖尿病患者替代指标的有效性。有趣的是,代谢负荷和高BMI可增加SAF，相当。总之,SAF可能在未来作为代谢综合征或糖尿病的标志物有所帮助。
