Abstract：
Nanogels are three-dimensional networks at the nanoscale level that can be fabricated through physical or chemical processes using polymers. These nanoparticles\' biocompatibility, notable stability, efficacious drug-loading capacity, and ligand-binding proficiency make them highly suitable for employment as drug-delivery vehicles. In addition, they exhibit the ability to react to both endogenous and exogenous stimuli, which may include factors such as temperature, illumination, pH levels, and a diverse range of other factors. This facilitates the consistent administration of the drug to the intended site. Alginate biopolymers have been utilized to encapsulate anticancer drugs due to their biocompatible nature, hydrophilic properties, and cost-effectiveness. The efficacy of alginate nano gel-based systems in cancer treatment has been demonstrated through multiple studies that endorse their progress toward clinical implementation. This paper comprehensively reviews alginate and its associated systems in drug delivery systems.
摘要：
纳米凝胶是纳米级的三维网络，可以通过使用聚合物的物理或化学过程来制造。这些纳米粒子的生物相容性，显著的稳定性，有效的载药量，和配体结合能力使它们非常适合用作药物递送工具。此外,它们表现出对内源性和外源性刺激作出反应的能力，其中可能包括温度等因素，照明,pH值,以及各种各样的其他因素。这有助于将药物一致地施用到预期部位。由于其生物相容性，海藻酸盐生物聚合物已被用于封装抗癌药物，亲水性能,和成本效益。基于藻酸盐纳米凝胶的系统在癌症治疗中的功效已通过多项研究得到证明，这些研究支持其在临床实施方面的进展。本文全面综述了海藻酸盐及其相关系统在药物递送系统中的应用。
