PDF(Pubmed)
Abstract：
BACKGROUND: Intrauterine microcephaly is a complex and lifelong condition that poses significant ethical challenges for clinicians and parents. The prognosis of microcephaly is highly variable and depends on the underlying cause and severity. In addition, microcephaly is often associated with various comorbidities, including intellectual disability, developmental delay, and epilepsy. Ultrasonography (US) is currently the most commonly used imaging modality for detecting microcephaly in the second trimester of pregnancy. However, antenatal brain magnetic resonance imaging (MRI) is increasingly being used as a more sensitive tool to identify structural abnormalities that may suggest a specific diagnosis. In this study, we report a case series of microcephaly diagnosed through the combination of MRI and US.
METHODS: How to utilize a combination of MRI and US to screen for fetal microcephaly.
METHODS: Based on the results of US and MRI examinations, patient 1 was found to have other craniocerebral malformations, patient 2 demonstrated macrogyria, and patient 3 exhibited skull irregularities.
METHODS: The pregnancies of all 3 patients were terminated through the induction of labor by injecting Rivanol into the amniotic cavity.
RESULTS: The 3 patients were discharged after a period of observation.
CONCLUSIONS: US is an important tool for diagnosing fetal microcephaly. However, MRI can overcome the limitations of US and detect additional brain structural abnormalities, thereby providing more specific and valuable prenatal diagnostic information. Therefore, combining MRI and US has significant diagnostic value for fetal microcephaly.
METHODS: How to utilize a combination of MRI and US to screen for fetal microcephaly.
METHODS: Based on the results of US and MRI examinations, patient 1 was found to have other craniocerebral malformations, patient 2 demonstrated macrogyria, and patient 3 exhibited skull irregularities.
METHODS: The pregnancies of all 3 patients were terminated through the induction of labor by injecting Rivanol into the amniotic cavity.
RESULTS: The 3 patients were discharged after a period of observation.
CONCLUSIONS: US is an important tool for diagnosing fetal microcephaly. However, MRI can overcome the limitations of US and detect additional brain structural abnormalities, thereby providing more specific and valuable prenatal diagnostic information. Therefore, combining MRI and US has significant diagnostic value for fetal microcephaly.
摘要：
背景：宫内小头畸形是一种复杂的终身性疾病，对临床医生和父母提出了重大的伦理挑战。小头畸形的预后是高度可变的，并且取决于潜在的原因和严重程度。此外,小头畸形通常与各种合并症有关，包括智力残疾，发育迟缓,和癫痫。超声检查（US）是目前用于检测妊娠中期小头畸形的最常用的成像方式。然而,产前脑磁共振成像(MRI)越来越多地被用作识别可能提示特定诊断的结构异常的更敏感工具.在这项研究中,我们报告了一系列通过MRI和US联合诊断的小头畸形病例。
方法：如何结合MRI和US筛查胎儿小头畸形。
方法：根据US和MRI检查结果，患者1被发现有其他颅脑畸形，患者2表现出宏观，患者3表现出颅骨不规则。
方法：3例患者均通过羊膜腔注射利凡诺引产终止妊娠。
结果：3例患者观察一段时间后出院。
结论：US是诊断胎儿小头畸形的重要工具。然而,MRI可以克服US的局限性并检测其他大脑结构异常，从而提供更具体和有价值的产前诊断信息。因此,联合MRI和US对胎儿小头畸形具有重要的诊断价值。
方法：如何结合MRI和US筛查胎儿小头畸形。
方法：根据US和MRI检查结果，患者1被发现有其他颅脑畸形，患者2表现出宏观，患者3表现出颅骨不规则。
方法：3例患者均通过羊膜腔注射利凡诺引产终止妊娠。
结果：3例患者观察一段时间后出院。
结论：US是诊断胎儿小头畸形的重要工具。然而,MRI可以克服US的局限性并检测其他大脑结构异常，从而提供更具体和有价值的产前诊断信息。因此,联合MRI和US对胎儿小头畸形具有重要的诊断价值。
