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Abstract：
BACKGROUND: Our study aimed to analyze the characteristics of ultrasound images corresponding to each histological stage of primary biliary cholangitis (PBC).
METHODS: We prospectively analyzed 75 confirmed cases of PBC and used liver biopsy as the gold standard to determine the disease stage.
RESULTS: The typical ultrasound images of patients with PBC were characterized by a thickening of the portal vein wall (PVW) and periportal hypoechoic band (PHB) width with increasing histological stages, and significant increases in the left hepatic lobe diameter (LHLD) in stage II (by 64.0%) and stage III (by 69.2%). PHB width (r = 0.857, p < 0.001), PVW thickness (r = 0.488, p < 0.001), and spleen area (r = 0.8774, p < 0.001) were positively correlated with the histological stage. Significant changes were noted in the liver surface, echo texture, and edge between different stages. The areas under the receiver operating characteristic curve of composite indicators were 0.965 for predicting progressive PBC(≥ stage 2), and 0.926 for predicting advanced PBC(≥ stage 3).
CONCLUSIONS: The ultrasound imaging characteristics of patients with PBC varied according to the histological staging. LHLD, PVW thickness, and PHB width were significantly correlated with the histological stage. A combination of high- and low-frequency ultrasound imaging can provide relevant cues regarding the degree of PBC progression and important clinical reference values. The application of all the ultrasound image findings as the composite indicators can better predict progressive and advanced PBC, providing important clinical reference values.
METHODS: We prospectively analyzed 75 confirmed cases of PBC and used liver biopsy as the gold standard to determine the disease stage.
RESULTS: The typical ultrasound images of patients with PBC were characterized by a thickening of the portal vein wall (PVW) and periportal hypoechoic band (PHB) width with increasing histological stages, and significant increases in the left hepatic lobe diameter (LHLD) in stage II (by 64.0%) and stage III (by 69.2%). PHB width (r = 0.857, p < 0.001), PVW thickness (r = 0.488, p < 0.001), and spleen area (r = 0.8774, p < 0.001) were positively correlated with the histological stage. Significant changes were noted in the liver surface, echo texture, and edge between different stages. The areas under the receiver operating characteristic curve of composite indicators were 0.965 for predicting progressive PBC(≥ stage 2), and 0.926 for predicting advanced PBC(≥ stage 3).
CONCLUSIONS: The ultrasound imaging characteristics of patients with PBC varied according to the histological staging. LHLD, PVW thickness, and PHB width were significantly correlated with the histological stage. A combination of high- and low-frequency ultrasound imaging can provide relevant cues regarding the degree of PBC progression and important clinical reference values. The application of all the ultrasound image findings as the composite indicators can better predict progressive and advanced PBC, providing important clinical reference values.
摘要：
背景：我们的研究旨在分析与原发性胆汁性胆管炎（PBC）的每个组织学阶段相对应的超声图像的特征。
方法：我们前瞻性分析了75例确诊的PBC病例，并将肝活检作为确定疾病分期的金标准。
结果：PBC患者的典型超声图像的特征是随着组织学分期的增加，门静脉壁（PVW）和门静脉周围低回声带（PHB）宽度增厚，在II期（64.0％）和III期（69.2％）中，左肝叶直径（LHLD）显着增加。PHB宽度（r=0.857，p<0.001），PVW厚度（r=0.488，p<0.001），脾脏面积(r=0.8774,p<0.001)与组织学分期呈正相关。肝脏表面有明显的变化，回声纹理,和边缘之间的不同阶段。综合指标的受试者工作特征曲线下面积为0.965，用于预测进行性PBC（≥阶段2），和0.926用于预测晚期PBC（≥3期）。
结论：PBC患者的超声影像学特征因组织学分期而异。LHLD,PVW厚度,PHB宽度与组织学分期显著相关。高频和低频超声成像的组合可以提供关于PBC进展程度的相关线索和重要的临床参考值。应用所有的超声图像结果作为综合指标,可以更好地预测进行性和晚期PBC,提供重要的临床参考价值。
方法：我们前瞻性分析了75例确诊的PBC病例，并将肝活检作为确定疾病分期的金标准。
结果：PBC患者的典型超声图像的特征是随着组织学分期的增加，门静脉壁（PVW）和门静脉周围低回声带（PHB）宽度增厚，在II期（64.0％）和III期（69.2％）中，左肝叶直径（LHLD）显着增加。PHB宽度（r=0.857，p<0.001），PVW厚度（r=0.488，p<0.001），脾脏面积(r=0.8774,p<0.001)与组织学分期呈正相关。肝脏表面有明显的变化，回声纹理,和边缘之间的不同阶段。综合指标的受试者工作特征曲线下面积为0.965，用于预测进行性PBC（≥阶段2），和0.926用于预测晚期PBC（≥3期）。
结论：PBC患者的超声影像学特征因组织学分期而异。LHLD,PVW厚度,PHB宽度与组织学分期显著相关。高频和低频超声成像的组合可以提供关于PBC进展程度的相关线索和重要的临床参考值。应用所有的超声图像结果作为综合指标,可以更好地预测进行性和晚期PBC,提供重要的临床参考价值。
