PDF(Pubmed)
Abstract：
The nuclear-localized lamins have long been thought to be the only intermediate filaments (IFs) with an impact on the architecture, properties, and functions of the nucleus. Recent studies, however, uncovered significant roles for IFs other than lamins (here referred to as \"non-lamin IFs\") in regulating key properties of the nucleus in various cell types and biological settings. In the cytoplasm, IFs often occur in the perinuclear space where they contribute to local stiffness and impact the shape and/or the integrity of the nucleus, particularly in cells under stress. In addition, selective non-lamin IF proteins can occur inside the nucleus where they partake in fundamental processes including nuclear architecture and chromatin organization, regulation of gene expression, cell cycle progression, and the repair of DNA damage. This text reviews the evidence supporting a role for non-lamin IF proteins in regulating various properties of the nucleus and highlights opportunities for further study.
摘要：
长期以来，人们一直认为核定位层是唯一对结构产生影响的中间细丝（IF）。属性,和核的功能。最近的研究,然而,揭示了在调节各种细胞类型和生物学环境中细胞核的关键特性方面，除了层粘连蛋白（此处称为“非层粘连蛋白IFs”）以外的IFs的重要作用。在细胞质中，IFs通常发生在核周空间，它们有助于局部刚度并影响核的形状和/或完整性。特别是在压力下的细胞中。此外,选择性非层粘连蛋白IF蛋白可以出现在细胞核内部，它们参与基本过程，包括核结构和染色质组织，基因表达的调节，细胞周期进程，和DNA损伤的修复。本文回顾了支持非层粘连蛋白IF蛋白在调节细胞核各种特性中的作用的证据，并强调了进一步研究的机会。
