Abstract：
Development of therapeutic agents that have fewer adverse effects and have higher efficacy for diseases, such as cancer, metabolic disorders, neurological diseases, infections, cardiovascular diseases, and respiratory diseases, are required. Recent studies have focused on identifying novel sources for pharmaceutical molecules to develop therapies against these diseases. Among the sources for potentially new therapies, animal venom-derived molecules have generated much interest. Various animal venom-derived proteins and peptides have been isolated, identified, synthesized, and tested to develop drugs. Venom-derived peptides have several biomedical properties, such as proapoptotic, cell migration, and autophagy regulation activities in cancer cell models; induction of vasodilation by nitric oxide and regulation of angiotensin II; modification of insulin response by controlling calcium and potassium channels; regulation of pain receptor activity; modulation of immune cell activity; alteration of motor neuron activity; degradation or inhibition of β-amyloid plaque formation; antibacterial, antifungal, antiviral, and antiprotozoal activities; increase in sperm motility and potentiation of erectile function; reduction of intraocular pressure; anticoagulation, fibrinolytic, and antithrombotic activities; etc. This systematic review compiles these biomedical properties and potential biomedical applications of synthesized animal venom-derived peptides reported in the latest research. In addition, the limitations and areas of opportunity in this research field are discussed so that new studies can be developed based on the data presented.
摘要：
开发副作用少、对疾病有较高疗效的治疗剂，比如癌症，代谢紊乱，神经系统疾病,感染,心血管疾病,和呼吸道疾病，是必需的。最近的研究集中在确定药物分子的新来源以开发针对这些疾病的疗法。在潜在新疗法的来源中，动物毒液衍生的分子引起了极大的兴趣。已分离出各种动物毒液来源的蛋白质和肽，已识别,合成，并测试以开发药物。毒液衍生的肽具有几种生物医学特性，如促凋亡，细胞迁移，和癌细胞模型中的自噬调节活性；一氧化氮诱导血管舒张和调节血管紧张素II；通过控制钙和钾通道修饰胰岛素反应；调节疼痛受体活性；调节免疫细胞活性；改变运动神经元活性；降解或抑制β-淀粉样斑块形成；抗菌，抗真菌药,抗病毒，和抗原生动物活性;精子运动性增加和勃起功能增强;眼内压降低;抗凝,纤维蛋白溶解,和抗血栓形成活性等。本文系统综述了最新研究报告的合成动物毒液衍生肽的这些生物医学特性和潜在的生物医学应用。此外,讨论了该研究领域的局限性和机会领域，以便可以根据所提供的数据开展新的研究。
