Abstract：
Naringin inhibits inflammation and oxidative stress, the P2 purinoreceptor X4 receptor (P2X4R) is associated with glial cell activation and inflammation, the purpose of this study is to investigate the effects of naringin on P2X4 receptor expression on satellite glial cells (SGCs) and its possible mechanisms. ATP promoted the SGC activation and upregulated P2X4R expression; naringin inhibited SGC activation, decreased expression of P2X4R, P38 MAPK/ERK, and NF-κB, and reduced levels of Ca2+, TNF-α, and IL-1β in SGCs in an ATP-containing environment. These findings suggest that naringin attenuates the ATP-induced SGC activation and reduces P2X4R expression via the Ca2+-P38 MAPK/ERK-NF-κB pathway.
摘要：
柚皮苷抑制炎症和氧化应激，P2嘌呤受体X4受体（P2X4R）与神经胶质细胞活化和炎症有关，目的探讨柚皮苷对卫星胶质细胞(SGCs)P2X4受体表达的影响及其可能机制。ATP促进SGC活化,上调P2X4R表达;柚皮苷抑制SGC活化,P2X4R的表达降低，P38MAPK/ERK,和NF-κB,和降低的Ca2+水平，TNF-α,在含ATP的环境中，SGCs中的IL-1β。这些发现表明柚皮苷通过Ca2-P38MAPK/ERK-NF-κB途径减弱ATP诱导的SGC激活并降低P2X4R表达。
