Abstract：
Non-alcoholic fatty liver disease (NAFLD is a spectrum of liver disease with a rising prevalence, ranging from simple steatosis to steatohepatitis and cirrhosis, where a significant minority face potential complications. Determining the predictive markers plays a crucial role. This study examined the relationship between serum uric acid (SUA) levels and NAFLD in healthy individuals and identified potential other predictors.
A cohort of 2162 healthy participants attending routine check-up visits between February 2021 and May 2023 were included. Participants underwent abdominal ultrasound, uric acid measurements, and anthropometric assessments by TANITA. NAFLD was graded using a \"hepatic steatosis score.\" Statistical analysis included nonparametric tests, chi-squared tests, Fisher\'s exact test, ROC curve analysis, and logistic regression.
The median age was 45 years (range:18-65). 1017 were male, and 1145 were female. Among the participants, 53.9%, 26.3%, 17.9%, and 1.9% exhibited Grade 0, 1, 2, and 3 hepatic steatosis, respectively. ROC analysis showed 80.0% sensitivity and 78.8% specificity for detecting grade 2 or higher hepatic steatosis with a cutoff value of 5.21 mg/dl of SUA (AUC = 0.82, p < 0.001, 95%CI 0.79-0.84). There were significant associations between elevated uric acid levels and NAFLD. Participants with higher body fat percentages, BMI values, and waist-to-hip ratios also demonstrated an increased prevalence of steatosis. Gender significantly influenced liver steatosis, with males exhibiting higher grades compared to females. Logistic regression analysis highlighted positive associations between NAFLD and body fat percentage, waist-to-hip ratio, and uric acid levels. Each unit increase in uric acid levels corresponded to a 2.5-fold increase in the odds of NAFLD (p < 0.001, 95% CI = 2.20-2.84).
Our findings suggest a significant relationship between serum uric acid levels and NAFLD in healthy individuals. Elevated uric acid levels, in conjunction with other anthropometric parameters, may serve as potential predictive markers for NAFLD.
A cohort of 2162 healthy participants attending routine check-up visits between February 2021 and May 2023 were included. Participants underwent abdominal ultrasound, uric acid measurements, and anthropometric assessments by TANITA. NAFLD was graded using a \"hepatic steatosis score.\" Statistical analysis included nonparametric tests, chi-squared tests, Fisher\'s exact test, ROC curve analysis, and logistic regression.
The median age was 45 years (range:18-65). 1017 were male, and 1145 were female. Among the participants, 53.9%, 26.3%, 17.9%, and 1.9% exhibited Grade 0, 1, 2, and 3 hepatic steatosis, respectively. ROC analysis showed 80.0% sensitivity and 78.8% specificity for detecting grade 2 or higher hepatic steatosis with a cutoff value of 5.21 mg/dl of SUA (AUC = 0.82, p < 0.001, 95%CI 0.79-0.84). There were significant associations between elevated uric acid levels and NAFLD. Participants with higher body fat percentages, BMI values, and waist-to-hip ratios also demonstrated an increased prevalence of steatosis. Gender significantly influenced liver steatosis, with males exhibiting higher grades compared to females. Logistic regression analysis highlighted positive associations between NAFLD and body fat percentage, waist-to-hip ratio, and uric acid levels. Each unit increase in uric acid levels corresponded to a 2.5-fold increase in the odds of NAFLD (p < 0.001, 95% CI = 2.20-2.84).
Our findings suggest a significant relationship between serum uric acid levels and NAFLD in healthy individuals. Elevated uric acid levels, in conjunction with other anthropometric parameters, may serve as potential predictive markers for NAFLD.
摘要：
■非酒精性脂肪性肝病（NAFLD是一种肝病，患病率上升，从简单的脂肪变性到脂肪性肝炎和肝硬化，大量的少数人面临潜在的并发症。确定预测标志物起着至关重要的作用。这项研究检查了健康个体中血清尿酸（SUA）水平与NAFLD之间的关系，并确定了其他潜在的预测因素。
■纳入了2021年2月至2023年5月期间参加例行检查的2162名健康参与者。参与者接受了腹部超声检查，尿酸测量，和TANITA的人体测量评估。NAFLD使用“肝脂肪变性评分”进行分级。“统计分析包括非参数检验，卡方检验,费希尔的精确检验，ROC曲线分析,和逻辑回归。
■中位年龄为45岁（范围：18-65）。1017是男性，1145名女性。在参与者中，53.9%,26.3%,17.9%,1.9%表现为0、1、2和3级肝性脂肪变性，分别。ROC分析显示，检测2级或更高级别肝脂肪变性的灵敏度为80.0%，特异性为78.8%，SUA的临界值为5.21mg/dl（AUC=0.82，p<0.001，95CI0.79-0.84）。尿酸水平升高与NAFLD之间存在显著关联。身体脂肪百分比较高的参与者，BMI值，腰臀比也显示脂肪变性的患病率增加.性别显著影响肝脏脂肪变性，与女性相比，男性表现出更高的成绩。Logistic回归分析强调NAFLD和体脂百分比之间的正相关，腰臀比,和尿酸水平。尿酸水平每增加一个单位，NAFLD的几率增加2.5倍（p<0.001，95％CI=2.20-2.84）。
■我们的研究结果表明，在健康个体中，血清尿酸水平与NAFLD之间存在显著关系。尿酸水平升高,结合其他人体测量参数，可作为NAFLD的潜在预测标志物。
■纳入了2021年2月至2023年5月期间参加例行检查的2162名健康参与者。参与者接受了腹部超声检查，尿酸测量，和TANITA的人体测量评估。NAFLD使用“肝脂肪变性评分”进行分级。“统计分析包括非参数检验，卡方检验,费希尔的精确检验，ROC曲线分析,和逻辑回归。
■中位年龄为45岁（范围：18-65）。1017是男性，1145名女性。在参与者中，53.9%,26.3%,17.9%,1.9%表现为0、1、2和3级肝性脂肪变性，分别。ROC分析显示，检测2级或更高级别肝脂肪变性的灵敏度为80.0%，特异性为78.8%，SUA的临界值为5.21mg/dl（AUC=0.82，p<0.001，95CI0.79-0.84）。尿酸水平升高与NAFLD之间存在显著关联。身体脂肪百分比较高的参与者，BMI值，腰臀比也显示脂肪变性的患病率增加.性别显著影响肝脏脂肪变性，与女性相比，男性表现出更高的成绩。Logistic回归分析强调NAFLD和体脂百分比之间的正相关，腰臀比,和尿酸水平。尿酸水平每增加一个单位，NAFLD的几率增加2.5倍（p<0.001，95％CI=2.20-2.84）。
■我们的研究结果表明，在健康个体中，血清尿酸水平与NAFLD之间存在显著关系。尿酸水平升高,结合其他人体测量参数，可作为NAFLD的潜在预测标志物。
