PDF(Pubmed)
Abstract：
Human serum albumin (HSA) is a multi-domain macromolecule with diverse ligand binding capability because of its ability to allow allosteric modulation despite being a monomeric protein. Physiologically, HSA act as the primary carrier for various exogenous and endogenous compounds and fatty acids, and alter the pharmacokinetic properties of several drugs. It has antioxidant properties and is utilized therapeutically to improve the drug delivery of pharmacological agents for the treatment of several disorders. The flexibility of albumin in holding various types of drugs coupled with a variety of modifications makes this protein a versatile drug carrier with incalculable potential in therapeutics. This review provides a brief outline of the different structural properties of HSA, and its various binding sites, moreover, an overview of the genetic, biomedical, and allosteric modulation of drugs and drug delivery aspects of HSA is also included, which may be helpful in guiding advanced clinical applications and further research on the therapeutic potential of this extraordinary protein.
摘要：
人血清白蛋白（HSA）是一种具有多种配体结合能力的多结构域大分子，尽管它是单体蛋白，但由于其允许变构调节的能力。生理学上,HSA作为各种外源性和内源性化合物和脂肪酸的主要载体，并改变几种药物的药代动力学特性。它具有抗氧化性质,并在治疗上用于改善用于治疗几种疾病的药理学试剂的药物递送。白蛋白在容纳各种类型的药物方面的灵活性以及多种修饰使得该蛋白质成为在治疗中具有无法估量的潜力的通用药物载体。这篇综述简要概述了HSA的不同结构特性，及其各种结合位点，此外,基因的概述，生物医学,还包括药物的变构调节和HSA的药物递送方面，这可能有助于指导先进的临床应用和进一步研究这种非凡的蛋白质的治疗潜力。
