PDF(Pubmed)
Abstract：
UNASSIGNED: Pseudorabies virus (PRV) is a linear DNA virus with a double-stranded structure, capable of infecting a diverse array of animal species, including humans. This study sought to ascertain the seroprevalence of Pseudorabies Virus (PRV) in China by conducting a comprehensive collection of blood samples from 16 provinces over the course of 2022.
UNASSIGNED: The presence of PRV gE antibodies was detected through the utilization of an enzyme-linked immunosorbent assay (ELISA) technique. Logistic regression analysis was conducted to identify potential related factors associated with the serologic status of PRV gE at the animal level. Additionally, the SaTScan 10.1 software was used to analyze the spatial and temporal clusters of PRV gE seroprevalence.
UNASSIGNED: A comprehensive collection of 161,880 samples was conducted, encompassing 556 swine farms throughout the country. The analysis revealed that the seroprevalence of PRV gE antibodies was 12.36% (95% confidence interval [CI], 12.20% to 12.52%) at the individual animal level. However, at the swine farm level, the seroprevalence was considerably higher, reaching 46.22% (95% CI, 42.08% to 50.37%). Related factors for PRV infection at the farm level included the geographic distribution of farms and seasonal variables. Moreover, five distinct high seroprevalence clusters of PRV gE were identified across China, with the peak prevalence observed during the months of April through June 2022.
UNASSIGNED: Our findings serve as a valuable addition to existing research on the seroprevalence, related factors, and temporal clustering of PRV gE in China. Furthermore, our study provides a reference point for the development of effective strategies for the prevention and control of pseudorabies and wild virus outbreaks.
UNASSIGNED: The presence of PRV gE antibodies was detected through the utilization of an enzyme-linked immunosorbent assay (ELISA) technique. Logistic regression analysis was conducted to identify potential related factors associated with the serologic status of PRV gE at the animal level. Additionally, the SaTScan 10.1 software was used to analyze the spatial and temporal clusters of PRV gE seroprevalence.
UNASSIGNED: A comprehensive collection of 161,880 samples was conducted, encompassing 556 swine farms throughout the country. The analysis revealed that the seroprevalence of PRV gE antibodies was 12.36% (95% confidence interval [CI], 12.20% to 12.52%) at the individual animal level. However, at the swine farm level, the seroprevalence was considerably higher, reaching 46.22% (95% CI, 42.08% to 50.37%). Related factors for PRV infection at the farm level included the geographic distribution of farms and seasonal variables. Moreover, five distinct high seroprevalence clusters of PRV gE were identified across China, with the peak prevalence observed during the months of April through June 2022.
UNASSIGNED: Our findings serve as a valuable addition to existing research on the seroprevalence, related factors, and temporal clustering of PRV gE in China. Furthermore, our study provides a reference point for the development of effective strategies for the prevention and control of pseudorabies and wild virus outbreaks.
摘要：
■伪狂犬病病毒（PRV）是一种具有双链结构的线性DNA病毒，能够感染各种各样的动物物种，包括人类。本研究旨在通过在2022年期间全面收集来自16个省的血液样本来确定中国伪狂犬病病毒（PRV）的血清阳性率。
■通过利用酶联免疫吸附测定（ELISA）技术检测PRVgE抗体的存在。进行Logistic回归分析以确定在动物水平上与PRVgE的血清学状态相关的潜在相关因素。此外,使用SaTScan10.1软件分析PRVgE血清阳性率的时空聚类.
■全面收集了161,880个样本，包括全国556个猪场。分析显示PRVgE抗体的血清阳性率为12.36%(95%置信区间[CI],12.20％至12.52％）在单个动物水平上。然而,在猪场一级，血清阳性率要高得多，达到46.22%（95%CI，42.08%至50.37%）。农场一级PRV感染的相关因素包括农场的地理分布和季节变量。此外，在中国各地发现了五个不同的PRVgE高血清阳性率簇，在2022年4月至6月期间观察到高峰患病率。
■我们的发现是对现有血清阳性率研究的宝贵补充，相关因素,中国PRVgE的时间聚类。此外，我们的研究为制定预防和控制伪狂犬病和野生病毒暴发的有效策略提供了参考。
■通过利用酶联免疫吸附测定（ELISA）技术检测PRVgE抗体的存在。进行Logistic回归分析以确定在动物水平上与PRVgE的血清学状态相关的潜在相关因素。此外,使用SaTScan10.1软件分析PRVgE血清阳性率的时空聚类.
■全面收集了161,880个样本，包括全国556个猪场。分析显示PRVgE抗体的血清阳性率为12.36%(95%置信区间[CI],12.20％至12.52％）在单个动物水平上。然而,在猪场一级，血清阳性率要高得多，达到46.22%（95%CI，42.08%至50.37%）。农场一级PRV感染的相关因素包括农场的地理分布和季节变量。此外，在中国各地发现了五个不同的PRVgE高血清阳性率簇，在2022年4月至6月期间观察到高峰患病率。
■我们的发现是对现有血清阳性率研究的宝贵补充，相关因素,中国PRVgE的时间聚类。此外，我们的研究为制定预防和控制伪狂犬病和野生病毒暴发的有效策略提供了参考。
