Abstract：
Systemic inflammation is a key contributor to the onset and progression of several obesity-associated diseases and is thought to predominantly arise from the hyperplasia and hypertrophy of white adipose tissue. However, a growing body of works suggests that early changes in the gastrointestinal (GI) barrier may contribute to both local, within the GI lining, and systemic inflammation in obesity. Intestinal barrier dysfunction is well-characterized in inflammatory GI disorders such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and is known to contribute to systemic inflammation. Thus, drawing parallels between GI disorders, where intestinal permeability and systemic inflammation are prominent features, and obesity-induced GI manifestations may provide insights into the potential role of the intestinal barrier in systemic inflammation in obesity. This review summarizes the current literature surrounding intestinal barrier dysfunction in obesity and explores the potential role of intestinal hyperpermeability and intestinal barrier dysfunction in the development of systemic inflammation and GI dysfunction in obesity.
摘要：
全身性炎症是几种肥胖相关疾病的发作和进展的关键因素,并且被认为主要起因于白色脂肪组织的增生和肥大。然而,越来越多的作品表明，胃肠道（GI）屏障的早期变化可能有助于局部，在GI衬里内，和肥胖的全身性炎症。肠屏障功能障碍在炎性GI病症如炎性肠病(IBD)和肠易激综合征(IBS)中被充分表征,并且已知有助于全身性炎症。因此，绘制胃肠道疾病之间的相似之处，肠道通透性和全身性炎症是突出的特征，和肥胖诱导的胃肠道表现可能有助于了解肠道屏障在肥胖全身性炎症中的潜在作用。本文综述了目前有关肥胖患者肠屏障功能障碍的相关文献,并探讨了肠通透性过高和肠屏障功能障碍在肥胖患者全身炎症和胃肠道功能障碍发生发展中的潜在作用。
