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Abstract：
Retroperitoneal liposarcoma (RLPS) poses a challenging scenario for surgeons due to its unpredictable biological behavior. Surgery remains the primary curative option for RLPS; however, the need for additional information to guide surgical strategies persists. Volume-based 18F-FDG PET/CT may solve this issue.
We analyzed data from 89 RLPS patients, measuring metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) and explored their associations with clinical, prognostic, and pathological factors.
MTV, TLG of multifocal and recurrent RLPS were significantly higher than unifocal and primary ones (P < 0.001, P < 0.001, P = 0.003 and P = 0.002, respectively). SUVmax correlated with FNCLCC histological grade, mitotic count and Ki-67 index (P for G1/G2 = 0.005, P for G2/G3 = 0.017, and P for G1/G3 = 0.001, P < 0.001 and P = 0.024, respectively). MTG, TLG and SUVmax of WDLPS were significantly lower than DDLPS and PLPS (P for MTV were 0.009 and 0.022, P for TLG were 0.028 and 0.048, and P for SUVmax were 0.027 and < 0.001, respectively). Multivariable Cox analysis showed that MTV > 457.65 (P = 0.025), pathological subtype (P = 0.049) and FNCLCC histological grade (P = 0.033) were related to overall survival (OS).
Our findings indicate that MTV is an independent prognostic factor for RLPS, while MTV, TLG, and SUVmax can preoperatively predict multifocal lesions, histological grade, and pathological subtype. Volume-based 18F-FDG PET/CT offers valuable information to aid in the decision-making process for RLPS surgical strategies.
We analyzed data from 89 RLPS patients, measuring metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) and explored their associations with clinical, prognostic, and pathological factors.
MTV, TLG of multifocal and recurrent RLPS were significantly higher than unifocal and primary ones (P < 0.001, P < 0.001, P = 0.003 and P = 0.002, respectively). SUVmax correlated with FNCLCC histological grade, mitotic count and Ki-67 index (P for G1/G2 = 0.005, P for G2/G3 = 0.017, and P for G1/G3 = 0.001, P < 0.001 and P = 0.024, respectively). MTG, TLG and SUVmax of WDLPS were significantly lower than DDLPS and PLPS (P for MTV were 0.009 and 0.022, P for TLG were 0.028 and 0.048, and P for SUVmax were 0.027 and < 0.001, respectively). Multivariable Cox analysis showed that MTV > 457.65 (P = 0.025), pathological subtype (P = 0.049) and FNCLCC histological grade (P = 0.033) were related to overall survival (OS).
Our findings indicate that MTV is an independent prognostic factor for RLPS, while MTV, TLG, and SUVmax can preoperatively predict multifocal lesions, histological grade, and pathological subtype. Volume-based 18F-FDG PET/CT offers valuable information to aid in the decision-making process for RLPS surgical strategies.
摘要：
目的：腹膜后脂肪肉瘤（RLPS）由于其不可预测的生物学行为而对外科医生构成了挑战性的情况。手术仍然是RLPS的主要治疗选择；然而，仍然需要额外的信息来指导手术策略.基于体积的18F-FDGPET/CT可以解决这个问题。
方法：我们分析了89例RLPS患者的数据，测量代谢性肿瘤体积（MTV），总病变糖酵解（TLG），和最大标准化摄取值(SUVmax)，并探讨了它们与临床的关联，预后，和病理因素。
结果：MTV，多灶性和复发性RLPS的TLG显着高于单灶性和原发性RLPS（分别为P<0.001，P<0.001，P=0.003和P=0.002）。SUVmax与FNCLCC组织学分级相关，有丝分裂计数和Ki-67指数（G1/G2的P=0.005，G2/G3的P=0.017，G1/G3的P=0.001，P<0.001和P=0.024）。MTG,WDLPS的TLG和SUVmax明显低于DDLPS和PLPS（MTV的P分别为0.009和0.022，TLG的P分别为0.028和0.048，SUVmax的P分别为0.027和<0.001）。多变量Cox分析表明MTV>457.65(P=0.025),病理亚型(P=0.049)和FNCLCC组织学分级(P=0.033)与总生存期(OS)相关。
结论：我们的研究结果表明，MTV是RLPS的独立预后因素，而MTV,TLG,SUVmax可以在术前预测多灶性病变，组织学分级,和病理亚型。基于体积的18F-FDGPET/CT为RLPS手术策略的决策过程提供了有价值的信息。
方法：我们分析了89例RLPS患者的数据，测量代谢性肿瘤体积（MTV），总病变糖酵解（TLG），和最大标准化摄取值(SUVmax)，并探讨了它们与临床的关联，预后，和病理因素。
结果：MTV，多灶性和复发性RLPS的TLG显着高于单灶性和原发性RLPS（分别为P<0.001，P<0.001，P=0.003和P=0.002）。SUVmax与FNCLCC组织学分级相关，有丝分裂计数和Ki-67指数（G1/G2的P=0.005，G2/G3的P=0.017，G1/G3的P=0.001，P<0.001和P=0.024）。MTG,WDLPS的TLG和SUVmax明显低于DDLPS和PLPS（MTV的P分别为0.009和0.022，TLG的P分别为0.028和0.048，SUVmax的P分别为0.027和<0.001）。多变量Cox分析表明MTV>457.65(P=0.025),病理亚型(P=0.049)和FNCLCC组织学分级(P=0.033)与总生存期(OS)相关。
结论：我们的研究结果表明，MTV是RLPS的独立预后因素，而MTV,TLG,SUVmax可以在术前预测多灶性病变，组织学分级,和病理亚型。基于体积的18F-FDGPET/CT为RLPS手术策略的决策过程提供了有价值的信息。
