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Abstract：
Bullous pemphigoid (BP) is an organ-specific disease. Its pathogenesis has not been clearly studied yet; However, studies in recent years have shown that its pathogenesis is related to T helper cells. The pathogenesis of BP is mainly related to Th2 and Th17-related cytokines. IL-4, IL-5 and IL-13 cause eosinophil recruitment, promote antibody production, trigger pruritus and promote blister formation and other symptoms. IL-17 and IL-23 promote the production of matrix metalloproteinase-9 (MMP-9) by related cells, which causes dermo-epidermal junction (DEJ) separation to form bullae and blisters, and can persist in BP inflammation. The serum concentrations of IL-17 and IL-23 are related to the prognosis of BP. In this paper, we focus on the role of related cytokines in the pathogenesis of bullous pemphigoid and the relationship between the related cytokine populations secreted by three major T helper cells-helper T lymphocytes 1 (Th1), Th2, and Th17. A better understanding of the biological and immunological functions of cytokines associated with BP patients will provide opportunities for therapeutic targets in BP.
摘要：
大疱性类天疱疮（BP）是一种器官特异性疾病。其发病机制尚未得到明确的研究;然而,近年来的研究表明其发病机制与辅助性T细胞有关。BP的发病机制主要与Th2和Th17相关细胞因子有关。IL-4，IL-5和IL-13引起嗜酸性粒细胞募集，促进抗体生产，引发瘙痒，促进水疱形成等症状。IL-17和IL-23促进相关细胞产生基质金属蛋白酶-9(MMP-9),导致真皮-表皮连接（DEJ）分离形成大疱和水泡，并能在BP炎症中持续存在。血清IL-17和IL-23的浓度与BP的预后有关。在本文中,我们关注相关细胞因子在大疱性类天疱疮发病机制中的作用，以及三种主要的辅助性T细胞-辅助性T淋巴细胞1（Th1）分泌的相关细胞因子群体之间的关系，Th2和Th17更好地了解与BP患者相关的细胞因子的生物学和免疫功能将为BP的治疗靶标提供机会。
