PDF(Pubmed)
Abstract：
UNASSIGNED: We sought to systematically review and summarize the peer-reviewed literature on urologic chronic pelvic pain syndrome flares, including their terminology, manifestation, perceived triggers, management and prevention strategies, impact on quality of life, and insights into pathophysiologic mechanisms, as a foundation for future empirical research.
UNASSIGNED: We searched 6 medical databases for articles related to any aspect of symptom exacerbations for interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome. A total of 1486 abstracts and 398 full-text articles were reviewed, and data were extracted by at least 2 individuals.
UNASSIGNED: Overall, we identified 59 articles, including 36 qualitative, cross-sectional, or case-control; 15 cohort-based; and 8 experimental articles. The majority of studies described North American patients with confirmed diagnoses. \"Flare\" was a commonly used term, but additional terminology (eg, exacerbation) was also used. Most flares involved significant increases in pain intensity, but less data were available on flare frequency and duration. Painful, frequent, long-lasting, and unpredictable flares were highly impactful, even over and above participants\' nonflare symptoms. A large number of perceived triggers (eg, diet, stress) and management/prevention strategies (eg, analgesics, thermal therapy, rest) were proposed by participants, but few had empirical support. In addition, few studies explored underlying biologic mechanisms.
UNASSIGNED: Overall, we found that flares are painful and impactful, but otherwise poorly understood in terms of manifestation (frequency and duration), triggers, treatment, prevention, and pathophysiology. These summary findings provide a foundation for future flare-related research and highlight gaps that warrant additional empirical studies.
UNASSIGNED: We searched 6 medical databases for articles related to any aspect of symptom exacerbations for interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome. A total of 1486 abstracts and 398 full-text articles were reviewed, and data were extracted by at least 2 individuals.
UNASSIGNED: Overall, we identified 59 articles, including 36 qualitative, cross-sectional, or case-control; 15 cohort-based; and 8 experimental articles. The majority of studies described North American patients with confirmed diagnoses. \"Flare\" was a commonly used term, but additional terminology (eg, exacerbation) was also used. Most flares involved significant increases in pain intensity, but less data were available on flare frequency and duration. Painful, frequent, long-lasting, and unpredictable flares were highly impactful, even over and above participants\' nonflare symptoms. A large number of perceived triggers (eg, diet, stress) and management/prevention strategies (eg, analgesics, thermal therapy, rest) were proposed by participants, but few had empirical support. In addition, few studies explored underlying biologic mechanisms.
UNASSIGNED: Overall, we found that flares are painful and impactful, but otherwise poorly understood in terms of manifestation (frequency and duration), triggers, treatment, prevention, and pathophysiology. These summary findings provide a foundation for future flare-related research and highlight gaps that warrant additional empirical studies.
摘要：
■为了系统地回顾和总结关于泌尿系慢性盆腔疼痛综合征（UCPPS）耀斑的同行评审文献，包括他们的术语，表现，感知到的触发器，管理和预防战略，对生活质量的影响，以及对病理生理机制的见解，作为未来实证研究的基础。
■我们在6个医学数据库中搜索了与间质性膀胱炎/膀胱疼痛综合征和慢性前列腺炎/慢性盆腔疼痛综合征症状恶化的任何方面相关的文章。审查了1486篇摘要和398篇全文文章，数据由至少两个人提取。
■总的来说，我们确定了59篇文章，包括36个定性的，横截面,或病例对照；15篇基于队列的；和8篇实验文章。大多数研究描述了确诊的北美患者。“耀斑”是一个常用的术语，但额外的术语(例如，加重）也被使用。大多数耀斑涉及疼痛强度的显着增加，但是关于耀斑频率和持续时间的数据较少。痛苦,频繁,持久的,不可预测的耀斑非常有影响力，甚至超过参与者的非耀斑症状。大量的感知触发因素(例如，饮食，压力)和管理/预防策略(例如，镇痛药,热疗,休息)是由与会者提出的，但很少有人有经验支持。此外,很少有研究探索潜在的生物学机制。
■总的来说，我们发现耀斑是痛苦和有影响的，但在表现(频率和持续时间)方面知之甚少，触发器,治疗,预防,和病理生理学。这些总结发现为未来与耀斑相关的研究奠定了基础，并强调了需要进行更多实证研究的差距。
■我们在6个医学数据库中搜索了与间质性膀胱炎/膀胱疼痛综合征和慢性前列腺炎/慢性盆腔疼痛综合征症状恶化的任何方面相关的文章。审查了1486篇摘要和398篇全文文章，数据由至少两个人提取。
■总的来说，我们确定了59篇文章，包括36个定性的，横截面,或病例对照；15篇基于队列的；和8篇实验文章。大多数研究描述了确诊的北美患者。“耀斑”是一个常用的术语，但额外的术语(例如，加重）也被使用。大多数耀斑涉及疼痛强度的显着增加，但是关于耀斑频率和持续时间的数据较少。痛苦,频繁,持久的,不可预测的耀斑非常有影响力，甚至超过参与者的非耀斑症状。大量的感知触发因素(例如，饮食，压力)和管理/预防策略(例如，镇痛药,热疗,休息)是由与会者提出的，但很少有人有经验支持。此外,很少有研究探索潜在的生物学机制。
■总的来说，我们发现耀斑是痛苦和有影响的，但在表现(频率和持续时间)方面知之甚少，触发器,治疗,预防,和病理生理学。这些总结发现为未来与耀斑相关的研究奠定了基础，并强调了需要进行更多实证研究的差距。
