Abstract:
Array based sensing governed by optical methods provides fast and economic way for detection of wide variety of analytes where the ideality of detection processes depends on the sensor element\'s versatile mode of interaction with multiple analytes in an unbiased manner. This can be achieved by either the receptor unit having multiple recognition moiety, or their surface property should possess tuning ability upon fabrication called surface engineering. Nanomaterials have a high surface to volume ratio, making them viable candidates for molecule recognition through surface adsorption phenomena, which makes it ideal to meet the above requirements. Most crucially, by engineering a nanomaterial\'s surface, one may produce cross-reactive responses for a variety of analytes while focusing solely on a single nanomaterial. Depending on the nature of receptor elements, in the last decade the array-based sensing has been considering as multimodal detection platform which operates through various pathway including single channel, multichannel, binding and indicator displacement assay, sequential ON-OFF sensing, enzyme amplified and nanozyme based sensing etc. In this review we will deliver the working principle for Array-based sensing by using various nanomaterials like nanoparticles, nanosheets, nanodots and self-assembled nanomaterials and their surface functionality for suitable molecular recognition.
摘要:
由光学方法控制的基于阵列的感测提供了用于检测各种分析物的快速且经济的方式,其中检测过程的理想性取决于传感器元件与多种分析物以无偏方式相互作用的通用模式。这可以通过具有多个识别部分的受体单元来实现,或者它们的表面性质在制造时应该具有调谐能力,称为表面工程。纳米材料具有很高的表面与体积比,通过表面吸附现象使它们成为分子识别的可行候选者,这使得它理想地满足上述要求。最关键的是,通过设计纳米材料的表面,人们可以产生对多种分析物的交叉反应响应,同时仅关注于单一纳米材料。根据受体元件的性质,在过去的十年中,基于阵列的传感一直被认为是多模态检测平台,它通过各种途径运行,包括单通道,多通道,结合和指示剂置换测定,顺序ON-OFF传感,酶扩增和基于纳米酶的传感等。在这篇综述中,我们将通过使用各种纳米材料(如纳米颗粒)来提供基于阵列的传感的工作原理,纳米片,纳米点和自组装纳米材料及其表面功能,用于合适的分子识别。