UNASSIGNED: In a prospective case-control study, blood samples from 66 patients with spontaneous POI and 66 healthy controls were analyzed for a series of autoimmune antibodies.
UNASSIGNED: POI women revealed significantly increased thyroglobulin antibodies (TGAb) (p = 0.045) and thyroid peroxidase antibodies (TPOAb) (p = 0.002). At least one abnormal autoimmune parameter was present in 37.9% of POI women, compared to 18.2% in healthy controls (p = 0.045). A strong association between POI and increased TGAb (adjusted odds ratio 3.586, p = 0.028), increased TPOAb (adjusted odds ratio 7.496, p = 0.003) and any increased autoimmune parameter (adjusted odds ratio 3.189, p = 0.008) could be demonstrated in a binary logistic regression model.
UNASSIGNED: A high prevalence of autoimmunity in POI women compared to a healthy young collective could be demonstrated. Thyroid antibodies were significantly increased in POI women. Our data highlight the increased risk for autoimmune diseases, especially for thyroid disorders.
■在一项前瞻性病例对照研究中,我们对66例自发性POI患者和66例健康对照者的血液样本进行了一系列自身免疫抗体分析.
■POI女性显示甲状腺球蛋白抗体(TGAb)(p=0.045)和甲状腺过氧化物酶抗体(TPOAb)(p=0.002)明显增加。在37.9%的POI女性中至少存在一个异常的自身免疫参数,相比之下,健康对照组为18.2%(p=0.045)。POI和增加的TGAb之间有很强的关联(调整后的赔率比3.586,p=0.028),TPOAb增加(调整后比值比7.496,p=0.003)和自身免疫参数增加(调整后比值比3.189,p=0.008)可以在二元逻辑回归模型中得到证实.
■可以证明,与健康的年轻集体相比,POI女性的自身免疫患病率很高。POI女性甲状腺抗体显著增高。我们的数据强调了自身免疫性疾病的风险增加,尤其是甲状腺疾病。