Abstract：
UNASSIGNED: Autoimmunity seems to be present in a large proportion of women with spontaneous premature ovarian insufficiency (POI). Whether these women are at increased risk for autoimmune disease has not been determined to date. Therefore, the aim of this study was to investigate a large series of antibodies in order to shed more light into the autoimmune risk of POI women.
UNASSIGNED: In a prospective case-control study, blood samples from 66 patients with spontaneous POI and 66 healthy controls were analyzed for a series of autoimmune antibodies.
UNASSIGNED: POI women revealed significantly increased thyroglobulin antibodies (TGAb) (p = 0.045) and thyroid peroxidase antibodies (TPOAb) (p = 0.002). At least one abnormal autoimmune parameter was present in 37.9% of POI women, compared to 18.2% in healthy controls (p = 0.045). A strong association between POI and increased TGAb (adjusted odds ratio 3.586, p = 0.028), increased TPOAb (adjusted odds ratio 7.496, p = 0.003) and any increased autoimmune parameter (adjusted odds ratio 3.189, p = 0.008) could be demonstrated in a binary logistic regression model.
UNASSIGNED: A high prevalence of autoimmunity in POI women compared to a healthy young collective could be demonstrated. Thyroid antibodies were significantly increased in POI women. Our data highlight the increased risk for autoimmune diseases, especially for thyroid disorders.
UNASSIGNED: In a prospective case-control study, blood samples from 66 patients with spontaneous POI and 66 healthy controls were analyzed for a series of autoimmune antibodies.
UNASSIGNED: POI women revealed significantly increased thyroglobulin antibodies (TGAb) (p = 0.045) and thyroid peroxidase antibodies (TPOAb) (p = 0.002). At least one abnormal autoimmune parameter was present in 37.9% of POI women, compared to 18.2% in healthy controls (p = 0.045). A strong association between POI and increased TGAb (adjusted odds ratio 3.586, p = 0.028), increased TPOAb (adjusted odds ratio 7.496, p = 0.003) and any increased autoimmune parameter (adjusted odds ratio 3.189, p = 0.008) could be demonstrated in a binary logistic regression model.
UNASSIGNED: A high prevalence of autoimmunity in POI women compared to a healthy young collective could be demonstrated. Thyroid antibodies were significantly increased in POI women. Our data highlight the increased risk for autoimmune diseases, especially for thyroid disorders.
摘要：
■自身免疫似乎存在于自发性早发卵巢功能不全（POI）的女性中。迄今为止，尚未确定这些妇女是否有自身免疫性疾病的风险增加。因此,这项研究的目的是调查一系列抗体,以进一步揭示POI女性的自身免疫风险.
■在一项前瞻性病例对照研究中，我们对66例自发性POI患者和66例健康对照者的血液样本进行了一系列自身免疫抗体分析.
■POI女性显示甲状腺球蛋白抗体（TGAb）（p=0.045）和甲状腺过氧化物酶抗体（TPOAb）（p=0.002）明显增加。在37.9%的POI女性中至少存在一个异常的自身免疫参数,相比之下，健康对照组为18.2%(p=0.045)。POI和增加的TGAb之间有很强的关联(调整后的赔率比3.586，p=0.028)，TPOAb增加(调整后比值比7.496,p=0.003)和自身免疫参数增加(调整后比值比3.189,p=0.008)可以在二元逻辑回归模型中得到证实.
■可以证明，与健康的年轻集体相比，POI女性的自身免疫患病率很高。POI女性甲状腺抗体显著增高。我们的数据强调了自身免疫性疾病的风险增加，尤其是甲状腺疾病。
■在一项前瞻性病例对照研究中，我们对66例自发性POI患者和66例健康对照者的血液样本进行了一系列自身免疫抗体分析.
■POI女性显示甲状腺球蛋白抗体（TGAb）（p=0.045）和甲状腺过氧化物酶抗体（TPOAb）（p=0.002）明显增加。在37.9%的POI女性中至少存在一个异常的自身免疫参数,相比之下，健康对照组为18.2%(p=0.045)。POI和增加的TGAb之间有很强的关联(调整后的赔率比3.586，p=0.028)，TPOAb增加(调整后比值比7.496,p=0.003)和自身免疫参数增加(调整后比值比3.189,p=0.008)可以在二元逻辑回归模型中得到证实.
■可以证明，与健康的年轻集体相比，POI女性的自身免疫患病率很高。POI女性甲状腺抗体显著增高。我们的数据强调了自身免疫性疾病的风险增加，尤其是甲状腺疾病。
