PDF(Pubmed)
Abstract：
UNASSIGNED: Although limited evidence exists on the beneficial reproductive effects of diet quality indices, the association is still largely unknown. We aimed to investigate the association between Diet Quality Index-International (DQI-I) and antral follicle count (AFC) and serum antimullerian hormone (AMH) as precise and sensitive markers of ovarian reserve and to assess the risk of diminished ovarian reserve (DOR) in women seeking fertility treatments.
UNASSIGNED: In a case-control study, 370 women (120 women with DOR and 250 women with normal ovarian reserve as controls), matched by age and body mass index (BMI), were recruited. Dietary intake was obtained using a validated 80-item semi-quantitative food frequency questionnaire (FFQ). The quality of diets was assessed using DQI-I, which included four major dietary components: variety (0-20 points), adequacy (0-40 points), moderation (0-30 points), and overall balance (0-10 points). DQI-I score was categorized by quartiles based on the distribution of controls. AFC, serum AMH and anthropometric indices were measured. Logistic regression models were used to estimate multivariable odds ratio (OR) of DOR across quartiles of DQI-I score.
UNASSIGNED: Increased adherence to DQI-I was associated with higher AFC in women with DOR. After adjusting for potential confounders, the odds of DOR decreased with increasing DQI-I score (0.39; 95% CI: 0.18-0.86).
UNASSIGNED: Greater adherence to DQI-I, as a food and nutrient-based quality index, may decrease the risk of DOR and improve the ovarian reserve in women already diagnosed with DOR. Our findings, though, need to be verified through prospective studies and clinical trials.
UNASSIGNED: In a case-control study, 370 women (120 women with DOR and 250 women with normal ovarian reserve as controls), matched by age and body mass index (BMI), were recruited. Dietary intake was obtained using a validated 80-item semi-quantitative food frequency questionnaire (FFQ). The quality of diets was assessed using DQI-I, which included four major dietary components: variety (0-20 points), adequacy (0-40 points), moderation (0-30 points), and overall balance (0-10 points). DQI-I score was categorized by quartiles based on the distribution of controls. AFC, serum AMH and anthropometric indices were measured. Logistic regression models were used to estimate multivariable odds ratio (OR) of DOR across quartiles of DQI-I score.
UNASSIGNED: Increased adherence to DQI-I was associated with higher AFC in women with DOR. After adjusting for potential confounders, the odds of DOR decreased with increasing DQI-I score (0.39; 95% CI: 0.18-0.86).
UNASSIGNED: Greater adherence to DQI-I, as a food and nutrient-based quality index, may decrease the risk of DOR and improve the ovarian reserve in women already diagnosed with DOR. Our findings, though, need to be verified through prospective studies and clinical trials.
摘要：
■尽管关于饮食质量指数的有益生殖影响的证据有限，这种联系在很大程度上仍然是未知的。我们旨在研究国际饮食质量指数（DQI-I）与窦卵泡计数（AFC）和血清抗苗勒管激素（AMH）作为卵巢储备的精确和敏感标志物之间的关系，并评估卵巢储备减少的风险（DOR）在寻求生育治疗的女性中。
■在一项病例对照研究中，370名女性（120名DOR女性和250名卵巢储备正常的女性作为对照），与年龄和体重指数（BMI）相匹配，被招募。使用经过验证的80项半定量食物频率问卷（FFQ）获得饮食摄入量。使用DQI-I评估饮食质量，其中包括四个主要的饮食成分：品种（0-20分），充分性（0-40分），温和（0-30分），和总体平衡（0-10分）。DQI-I评分根据对照的分布按四分位数进行分类。AFC,测量血清AMH和人体测量指标。采用Logistic回归模型估计DQI-I分四分位数间DOR的多变量比值比(OR)。
■DQI-I依从性增加与DOR女性AFC升高相关。在调整了潜在的混杂因素后，DOR的几率随着DQI-I评分的增加而降低(0.39;95%CI:0.18-0.86)。
■更加坚持DQI-I，作为基于食物和营养的质量指标，可能降低DOR的风险并改善已诊断为DOR的女性的卵巢储备。我们的发现,虽然,需要通过前瞻性研究和临床试验进行验证。
■在一项病例对照研究中，370名女性（120名DOR女性和250名卵巢储备正常的女性作为对照），与年龄和体重指数（BMI）相匹配，被招募。使用经过验证的80项半定量食物频率问卷（FFQ）获得饮食摄入量。使用DQI-I评估饮食质量，其中包括四个主要的饮食成分：品种（0-20分），充分性（0-40分），温和（0-30分），和总体平衡（0-10分）。DQI-I评分根据对照的分布按四分位数进行分类。AFC,测量血清AMH和人体测量指标。采用Logistic回归模型估计DQI-I分四分位数间DOR的多变量比值比(OR)。
■DQI-I依从性增加与DOR女性AFC升高相关。在调整了潜在的混杂因素后，DOR的几率随着DQI-I评分的增加而降低(0.39;95%CI:0.18-0.86)。
■更加坚持DQI-I，作为基于食物和营养的质量指标，可能降低DOR的风险并改善已诊断为DOR的女性的卵巢储备。我们的发现,虽然,需要通过前瞻性研究和临床试验进行验证。
