PDF(Pubmed)
Abstract：
Prebiotics exert favorable effects on the host through interactions with probiotics, and their beneficial impacts have been extensively validated across various chronic ailments, including diabetes. This study presents findings from a case-control investigation involving 10 individuals with type 2 diabetes mellitus (T2DM) and 10 healthy counterparts. Fresh stool specimens were collected from all participants. Following a 24-h fermentation period in mediums containing xylitol and mannitol, the observed increase in Lactobacillus abundance within the case group exceeded that of the control group. Similarly, in mediums containing soluble starch, choline, and L-carnitine, the augmentation of Bifidobacterium within the case group surpassed that of the controls. Notably, a statistically significant divergence in sugar degradation rate emerged between the case and control groups, specifically in the medium harboring lactulose and isomalto-oligosaccharides. Remarkably, the degradation rate of lactulose exhibited a positive correlation with the expansion of Bifidobacterium (R 2 = .147, p = .037). Likewise, the degradation rate of isomalto-oligosaccharides demonstrated a positive correlation with Bifidobacterium proliferation (R 2 = .165, p = .041). In conclusion, prebiotics like xylitol and mannitol exhibit the capacity to enhance intestinal probiotic populations in individuals newly diagnosed with diabetes. The modifications in the intestinal flora homeostasis of diabetic patients may be evidenced by alterations in the degradation rate of specific prebiotic substrates.
摘要：
益生元通过与益生菌的相互作用对宿主产生有利的影响，它们的有益影响已经在各种慢性病中得到了广泛的验证，包括糖尿病.这项研究提供了一项病例对照研究的结果，该研究涉及10名2型糖尿病（T2DM）患者和10名健康者。从所有参与者收集新鲜粪便标本。在含有木糖醇和甘露醇的培养基中发酵24小时后，观察到的病例组中乳酸菌丰度的增加超过了对照组。同样，在含有可溶性淀粉的培养基中，胆碱，和左旋肉碱,病例组中双歧杆菌的增加超过了对照组。值得注意的是,病例组和对照组之间的糖降解率出现了统计学上显著的差异，特别是在含有乳果糖和异麦芽寡糖的培养基中。值得注意的是,乳果糖的降解率与双歧杆菌的扩增呈正相关（R2=.147，p=.037）。同样，异麦芽寡糖的降解率与双歧杆菌的增殖呈正相关(R2=.165,p=.041)。总之,诸如木糖醇和甘露醇之类的益生元具有增强新诊断为糖尿病的个体的肠道益生菌群的能力。糖尿病患者肠道菌群稳态的改变可以通过特定益生元底物的降解速率的改变来证明。
