PDF(Pubmed)
Abstract：
UNASSIGNED: Although urothelial carcinoma (UC) generally is non-invasive, contrastingly in 25% of patients UC metastasizes. Isolated central nervous system (CNS) metastasis from UC without other distant metastases are considered rare. In this report we describe a patient with an isolated and solitary cerebellar metastasis from UC.
UNASSIGNED: In this case report we explore the value of histological analysis of CNS metastases, imaging, treatment options and survival.
UNASSIGNED: A rare case is presented of a patient diagnosed with an isolated CNS metastasis originating from UC. Through a systematic review of literature route of dissemination, current imaging and treatment options, and survival are discussed.
UNASSIGNED: A 77-year-old male was diagnosed with a pT2N0M0 high-grade UC and treated with transurethral resection and chemoradiation therapy. Several months later, the patient presented with neurological symptoms, and radiological imaging revealed a solitary cerebellar mass. A body CT scan showed no other metastasis. After surgical resection, histology confirmed urothelial origin of the mass, matching his primary UC and the patient received post-operative stereotactic radiotherapy at the surgical site. Recurrence of the cerebellar mass occurred after 6 months for which the patient received re-resection. The patient died 5.5 months after re-resection.
UNASSIGNED: Isolated brain metastases without other distant metastases from UC are rare, so histologic confirmation of the brain metastasis is essential, particularly when the time interval between diagnosis of the UC and brain metastasis increases. Early brain CT is not recommended. PET CT may have additional value in detection of other distant metastases from UC. Despite advancements in treatments, prognosis for CNS metastasis from UC remains poor.
UNASSIGNED: In this case report we explore the value of histological analysis of CNS metastases, imaging, treatment options and survival.
UNASSIGNED: A rare case is presented of a patient diagnosed with an isolated CNS metastasis originating from UC. Through a systematic review of literature route of dissemination, current imaging and treatment options, and survival are discussed.
UNASSIGNED: A 77-year-old male was diagnosed with a pT2N0M0 high-grade UC and treated with transurethral resection and chemoradiation therapy. Several months later, the patient presented with neurological symptoms, and radiological imaging revealed a solitary cerebellar mass. A body CT scan showed no other metastasis. After surgical resection, histology confirmed urothelial origin of the mass, matching his primary UC and the patient received post-operative stereotactic radiotherapy at the surgical site. Recurrence of the cerebellar mass occurred after 6 months for which the patient received re-resection. The patient died 5.5 months after re-resection.
UNASSIGNED: Isolated brain metastases without other distant metastases from UC are rare, so histologic confirmation of the brain metastasis is essential, particularly when the time interval between diagnosis of the UC and brain metastasis increases. Early brain CT is not recommended. PET CT may have additional value in detection of other distant metastases from UC. Despite advancements in treatments, prognosis for CNS metastasis from UC remains poor.
摘要：
■尽管尿路上皮癌（UC）通常是非侵袭性的，相反，在25％的患者UC转移。从UC分离的中枢神经系统（CNS）转移而没有其他远处转移被认为是罕见的。在本报告中，我们描述了一名患有UC的孤立性和孤立性小脑转移的患者。
■在本病例报告中，我们探讨了中枢神经系统转移的组织学分析的价值，成像,治疗选择和生存。
■出现了一个罕见病例，该患者被诊断患有源自UC的孤立的CNS转移。通过对文献传播途径的系统回顾,当前的成像和治疗选择，和生存讨论。
■一名77岁男性被诊断为pT2N0M0高级别UC，并接受经尿道切除和放化疗治疗。几个月后,病人出现神经症状,放射学成像显示一个孤立的小脑肿块。身体CT扫描显示无其他转移。手术切除后,组织学证实了肿块的尿路上皮起源，匹配他的原发性UC和患者在手术部位接受了术后立体定向放疗.患者接受再切除6个月后，小脑肿块复发。患者在再次切除后5.5个月死亡。
■孤立的脑转移没有UC的其他远处转移是罕见的，所以脑转移的组织学确认是至关重要的，特别是当诊断UC和脑转移之间的时间间隔增加时。不建议早期脑部CT检查。PETCT在检测UC的其他远处转移中可能具有附加价值。尽管在治疗方面取得了进展，UCCNS转移的预后仍然较差。
■在本病例报告中，我们探讨了中枢神经系统转移的组织学分析的价值，成像,治疗选择和生存。
■出现了一个罕见病例，该患者被诊断患有源自UC的孤立的CNS转移。通过对文献传播途径的系统回顾,当前的成像和治疗选择，和生存讨论。
■一名77岁男性被诊断为pT2N0M0高级别UC，并接受经尿道切除和放化疗治疗。几个月后,病人出现神经症状,放射学成像显示一个孤立的小脑肿块。身体CT扫描显示无其他转移。手术切除后,组织学证实了肿块的尿路上皮起源，匹配他的原发性UC和患者在手术部位接受了术后立体定向放疗.患者接受再切除6个月后，小脑肿块复发。患者在再次切除后5.5个月死亡。
■孤立的脑转移没有UC的其他远处转移是罕见的，所以脑转移的组织学确认是至关重要的，特别是当诊断UC和脑转移之间的时间间隔增加时。不建议早期脑部CT检查。PETCT在检测UC的其他远处转移中可能具有附加价值。尽管在治疗方面取得了进展，UCCNS转移的预后仍然较差。
