METHODS: NLR and PLR were measured in 53 patients (median age: 12.9 years), including 17 on dialysis and 36 with a median glomerular filtration rate of 39 ml/min/1.73m2, and in 25 age and sex-matched healthy controls. Iron profile, serum albumin and IL-6 were measured in the patient group. IL-6 levels > 3rd quartile were classified as high.
RESULTS: Patients presented higher NLR and PLR and particularly those on dialysis (p < 0.001 and p = 0.001). We observed a significant correlation between natural logarithm (ln) of IL-6 (lnIL-6) and NLR (rs = 0.344, p = 0.014), serum albumin (rs = -0.350, p = 0.011) and TIBC (rs = -0.345, p = 0.012) after adjustment for CKD stage, while the correlation between lnIL-6 and PLR was not significant (rs = 0.206, p = 0.151). Combination of NLR, serum albumin and TIBC predicted high IL-6 (13 patients) with an AUC of 0.771 (95% CI 0.608-0.943). Pairing of NLR ≥ 1.7 and TIBC ≤ 300 μg/dL exhibited the highest sensitivity (76.9%), while incorporating serum albumin ≤ 3.8 g/dL along with them achieved the highest specificity (95%) for detecting high IL-6 levels.
CONCLUSIONS: Both NLR and PLR levels increase in CKD, especially in patients on chronic dialysis. NLR, rather than PLR, along with TIBC and serum albumin, are associated with IL-6 in pediatric CKD.
方法:对53例患者(中位年龄:12.9岁)的NLR和PLR进行了测量,其中包括17例透析患者和36例肾小球滤过率中位数为39ml/min/1.73m2,以及25例年龄和性别匹配的健康对照。铁轮廓,在患者组中测量血清白蛋白和IL-6。IL-6水平>第3四分位数被分类为高。
结果:患者表现出较高的NLR和PLR,尤其是透析患者(p<0.001和p=0.001)。我们观察到IL-6的自然对数(ln)(lnIL-6)和NLR(rs=0.344,p=0.014)之间的显着相关性,血清白蛋白(rs=-0.350,p=0.011)和TIBC(rs=-0.345,p=0.012)在调整CKD分期后,lnIL-6与PLR之间的相关性不显着(rs=0.206,p=0.151)。NLR的组合,血清白蛋白和TIBC预测高IL-6(13例),AUC为0.771(95%CI0.608-0.943)。NLR≥1.7和TIBC≤300μg/dL的配对表现出最高的灵敏度(76.9%),同时掺入血清白蛋白≤3.8g/dL时,检测高IL-6水平的特异性最高(95%)。
结论:CKD患者NLR和PLR水平均升高,尤其是慢性透析患者。NLR,而不是PLR,连同TIBC和血清白蛋白,在小儿CKD中与IL-6相关。