Abstract：
UNASSIGNED: Many risk factors in uterine fibroid development have been identified, but women and their physicians are less aware of the influence of lifestyle on uterine fibroid development. The objective of this systematic review is to investigate and summarize modifiable prognostic factors associated with uterine fibroid development.
UNASSIGNED: Pubmed and Embase were searched for relevant articles according to PRISMA guidelines. References from included articles were screened and when relevant also included. Human in vivo studies on modifiable factors in fibroid development were included. Studies on non-modifiable factors and treatment, in vitro studies and animal studies were excluded. 607 articles were screened and 33 articles were included. Two independent investigators collected data from the report.
UNASSIGNED: The strongest risk factor for fibroid development was a high BMI, while the strongest protective factors were a high fruit and vegetable intake and high vitamin D intake.
UNASSIGNED: More high-quality studies are necessary to better understand the impact of the abovementioned factors as well as the role they play in the growth of already existing fibroids.
Uterine fibroid development is multifactorial. Various non-modifiable and modifiable factors have been linked to uterine fibroid development. Modifiable factors are controllable by patients themselves. We performed a systematic review to investigate these modifiable factors. We screened 607 articles from 2 databases (PubMed and Embase) of which 33 were included in the review. We only included clinical studies on humans. A high body mass index (BMI) is found to be a modifiable risk factor for uterine fibroid development. Protective of uterine fibroid development are high fruit and vegetable intake and high vitamin D intake or sun exposure. More research is needed to investigate the applicability of these findings in clinical practice and to investigate the influence on the growth of already existing uterine fibroids.
UNASSIGNED: Pubmed and Embase were searched for relevant articles according to PRISMA guidelines. References from included articles were screened and when relevant also included. Human in vivo studies on modifiable factors in fibroid development were included. Studies on non-modifiable factors and treatment, in vitro studies and animal studies were excluded. 607 articles were screened and 33 articles were included. Two independent investigators collected data from the report.
UNASSIGNED: The strongest risk factor for fibroid development was a high BMI, while the strongest protective factors were a high fruit and vegetable intake and high vitamin D intake.
UNASSIGNED: More high-quality studies are necessary to better understand the impact of the abovementioned factors as well as the role they play in the growth of already existing fibroids.
Uterine fibroid development is multifactorial. Various non-modifiable and modifiable factors have been linked to uterine fibroid development. Modifiable factors are controllable by patients themselves. We performed a systematic review to investigate these modifiable factors. We screened 607 articles from 2 databases (PubMed and Embase) of which 33 were included in the review. We only included clinical studies on humans. A high body mass index (BMI) is found to be a modifiable risk factor for uterine fibroid development. Protective of uterine fibroid development are high fruit and vegetable intake and high vitamin D intake or sun exposure. More research is needed to investigate the applicability of these findings in clinical practice and to investigate the influence on the growth of already existing uterine fibroids.
摘要：
■已经确定了子宫肌瘤发展中的许多危险因素，但是女性和她们的医生很少意识到生活方式对子宫肌瘤发育的影响。本系统综述的目的是研究和总结与子宫肌瘤发展相关的可改变的预后因素。
■根据PRISMA指南搜索Pubmed和Embase的相关文章。筛选来自所包括的文章的参考文献,并且在相关时还包括。包括对肌瘤发育中可改变因子的人体体内研究。关于不可改变因素和治疗的研究，体外研究和动物研究被排除.共筛选了607篇，共纳入33篇。两名独立调查人员从报告中收集数据。
■肌瘤发展的最大危险因素是高BMI，而最强的保护因素是高水果和蔬菜摄入量和高维生素D摄入量。
■需要更多高质量的研究来更好地了解上述因素的影响以及它们在已经存在的肌瘤生长中的作用。
子宫肌瘤的发展是多因素的。各种不可改变和可改变的因素与子宫肌瘤的发展有关。可改变的因素可由患者自己控制。我们进行了系统评价以调查这些可改变的因素。我们从2个数据库（PubMed和Embase）中筛选了607篇文章，其中33篇被纳入综述。我们只包括对人类的临床研究。发现高体重指数（BMI）是子宫肌瘤发展的可改变的危险因素。保护子宫肌瘤的发展是高水果和蔬菜的摄入量和高维生素D的摄入量或阳光暴晒。需要更多的研究来研究这些发现在临床实践中的适用性，并研究对已经存在的子宫肌瘤生长的影响。
■根据PRISMA指南搜索Pubmed和Embase的相关文章。筛选来自所包括的文章的参考文献,并且在相关时还包括。包括对肌瘤发育中可改变因子的人体体内研究。关于不可改变因素和治疗的研究，体外研究和动物研究被排除.共筛选了607篇，共纳入33篇。两名独立调查人员从报告中收集数据。
■肌瘤发展的最大危险因素是高BMI，而最强的保护因素是高水果和蔬菜摄入量和高维生素D摄入量。
■需要更多高质量的研究来更好地了解上述因素的影响以及它们在已经存在的肌瘤生长中的作用。
子宫肌瘤的发展是多因素的。各种不可改变和可改变的因素与子宫肌瘤的发展有关。可改变的因素可由患者自己控制。我们进行了系统评价以调查这些可改变的因素。我们从2个数据库（PubMed和Embase）中筛选了607篇文章，其中33篇被纳入综述。我们只包括对人类的临床研究。发现高体重指数（BMI）是子宫肌瘤发展的可改变的危险因素。保护子宫肌瘤的发展是高水果和蔬菜的摄入量和高维生素D的摄入量或阳光暴晒。需要更多的研究来研究这些发现在临床实践中的适用性，并研究对已经存在的子宫肌瘤生长的影响。
