Abstract：
An adult sulphur-crested cockatoo (Cacatua galerita) was unexpectedly found dead and was presented for post-mortem examination. Macroscopically, the proventricular wall was expanded by an infiltrative off-white mass, 10 mm in diameter, with secondary mucosal ulceration. Cytological examination of impression smears revealed a neoplastic epithelial cell population forming occasional well-defined acini with secretory product. Histologically, the neoplastic cells were predominantly arranged in acini and tubules, with fewer in small clusters, supported by a desmoplastic stroma. Neoplastic cells were polygonal, with mostly well-demarcated cell boundaries and a moderate amount of eosinophilic cytoplasm that was multifocally markedly distended by more intensely eosinophilic material. There was an increased nuclear-to-cytoplasmic ratio with moderately sized to large nuclei (approximately 15 μm diameter) with lightly to densely stippled chromatin and single or paired prominent basophilic nucleoli. The mitotic count was 19 in 10 high-power fields (2.37 mm2), with scattered bizarre mitotic figures and atypia including moderate anisocytosis and anisokaryosis and moderate cellular and nuclear pleomorphism. There was frequent intratubular brightly eosinophilic proteinaceous material, which was Alcian blue and periodic acid‒Schiff positive. Proventricular lymphovascular invasion was detected, with metastases within the ventriculus and lungs. The macroscopic, cytological and histological appearance of the neoplasm was consistent with a proventricular adenocarcinoma.
摘要：
意外发现成年硫冠凤头鹦鹉（Cacatuagalerita）死亡，并进行验尸。宏观上,前室壁被浸润的灰白色肿块扩张，直径10mm,继发粘膜溃疡。印模涂片的细胞学检查显示，肿瘤上皮细胞群偶尔形成清晰的腺泡，并带有分泌产物。组织学上,肿瘤细胞主要排列在腺泡和小管中，在小集群中更少，由促纤维增生基质支持。肿瘤细胞呈多边形,大部分细胞边界清晰，中等数量的嗜酸性细胞浆被更强烈的嗜酸性物质多灶性明显扩张。细胞核与细胞质的比率增加，细胞核大小适中至较大（直径约15μm），染色质轻度至浓密点状，单个或配对明显的嗜碱性核仁。在10个高功率场（2.37mm2）中，有丝分裂计数为19，具有分散的奇异的有丝分裂图和异型性，包括中度的无异型细胞增生和无异型增生以及中度的细胞和核多态性。有常见的肾小管内明亮的嗜酸性蛋白物质，这是阿尔辛蓝和高碘酸希夫阳性。检测到前室淋巴血管侵犯，在脑室和肺部有转移.宏观的，肿瘤的细胞学和组织学表现与前室腺癌一致。
