PDF(Pubmed)
Abstract：
Liposarcomas are a prevalent subtype of soft tissue sarcomas, constituting less than 1% of all malignancies. Originating in the adipose tissue, they can manifest in various locations and are categorized by the World Health Organization into several subtypes: well-differentiated liposarcomas, dedifferentiated liposarcomas, myxoid liposarcomas, pleomorphic liposarcomas and mixed-type liposarcomas. These tumors typically affect middle-aged and older individuals, and their incidence has been progressively increasing over the years. As liposarcomas advance they tend to encase blood vessels and major organs, particularly in the retroperitoneal area. Often asymptomatic initially, symptoms arise as the tumor reaches a considerable size, exerting pressure on adjacent tissues and organs. This report features a 54-year-old patient incidentally diagnosed with a substantial retroperitoneal tumor extending to the antero-lateral abdominal wall and inner thigh via the right inguinal ligament. The patient, with a previous three-year history of a right inguinal mass, sought acute care for a perianal abscess The histological examination revealed morphological aspects consistent with a low-grade myxoid liposarcoma. While surgery remains the primary treatment for retroperitoneal liposarcomas, controversies exist regarding the role of radiotherapy and chemotherapy in improving survival rates. This case highlights the challenges in managing retroperitoneal tumors and underscores the importance of a personalized, multidisciplinary approach to optimize patient outcomes.
摘要：
脂肪肉瘤是软组织肉瘤的一种常见亚型,占所有恶性肿瘤的不到1%。起源于脂肪组织，它们可以在不同的位置出现，并被世界卫生组织分为几个亚型：分化良好的脂肪肉瘤，去分化脂肪肉瘤,粘液样脂肪肉瘤，多形性脂肪肉瘤和混合型脂肪肉瘤。这些肿瘤通常影响中老年人，多年来，它们的发病率逐渐增加。随着脂肪肉瘤的发展，它们倾向于包裹血管和主要器官，特别是在腹膜后区域。通常最初无症状，当肿瘤达到相当大的尺寸时，症状就会出现，对邻近的组织和器官施加压力。本报告以一名54岁的患者为特征，该患者偶然被诊断为腹膜后肿瘤，经右腹股沟韧带延伸到前外侧腹壁和大腿内侧。病人,有三年的右腹股沟肿块病史，寻求肛周脓肿的急性治疗组织学检查显示，形态学方面与低度粘液样脂肪肉瘤一致。虽然手术仍然是腹膜后脂肪肉瘤的主要治疗方法，关于放疗和化疗在提高生存率方面的作用存在争议。这个案例突出了腹膜后肿瘤管理的挑战，并强调了个性化的重要性，优化患者预后的多学科方法。
