PDF(Pubmed)
Abstract：
UNASSIGNED: Quorum sensing is bacteria\'s ability to communicate and regulate their behavior based on population density. Anti-quorum sensing agents (anti-QSA) is promising strategy to treat resistant infections, as well as reduce selective pressure that leads to antibiotic resistance of clinically relevant pathogens. This study analyzes the output, hotspots, and trends of research in the field of anti-QSA against clinically relevant pathogens.
UNASSIGNED: The literature on anti-QSA from the Web of Science Core Collection database was retrieved and analyzed. Tools such as CiteSpace and Alluvial Generator were used to visualize and interpret the data.
UNASSIGNED: From 1998 to 2023, the number of publications related to anti-QAS research increased rapidly, with a total of 1,743 articles and reviews published in 558 journals. The United States was the largest contributor and the most influential country, with an H-index of 88, higher than other countries. Williams was the most productive author, and Hoiby N was the most cited author. Frontiers in Microbiology was the most prolific and the most cited journal. Burst detection indicated that the main frontier disciplines shifted from MICROBIOLOGY, CLINICAL, MOLECULAR BIOLOGY, and other biomedicine-related fields to FOOD, MATERIALS, NATURAL PRODUCTS, and MULTIDISCIPLINARY. In the whole research history, the strongest burst keyword was cystic-fibrosis patients, and the strongest burst reference was Lee and Zhang (2015). In the latest period (burst until 2023), the strongest burst keyword was silver nanoparticle, and the strongest burst reference was Whiteley et al. (2017). The co-citation network revealed that the most important interest and research direction was anti-biofilm/anti-virulence drug development, and timeline analysis suggested that this direction is also the most active. The key concepts alluvial flow visualization revealed seven terms with the longest time span and lasting until now, namely Escherichia coli, virulence, Pseudomonas aeruginosa, virulence factor, bacterial biofilm, gene expression, quorum sensing. Comprehensive analysis shows that nanomaterials, marine natural products, and artificial intelligence (AI) may become hotspots in the future.
UNASSIGNED: This bibliometric study reveals the current status and trends of anti-QSA research and may assist researchers in identifying hot topics and exploring new research directions.
UNASSIGNED: The literature on anti-QSA from the Web of Science Core Collection database was retrieved and analyzed. Tools such as CiteSpace and Alluvial Generator were used to visualize and interpret the data.
UNASSIGNED: From 1998 to 2023, the number of publications related to anti-QAS research increased rapidly, with a total of 1,743 articles and reviews published in 558 journals. The United States was the largest contributor and the most influential country, with an H-index of 88, higher than other countries. Williams was the most productive author, and Hoiby N was the most cited author. Frontiers in Microbiology was the most prolific and the most cited journal. Burst detection indicated that the main frontier disciplines shifted from MICROBIOLOGY, CLINICAL, MOLECULAR BIOLOGY, and other biomedicine-related fields to FOOD, MATERIALS, NATURAL PRODUCTS, and MULTIDISCIPLINARY. In the whole research history, the strongest burst keyword was cystic-fibrosis patients, and the strongest burst reference was Lee and Zhang (2015). In the latest period (burst until 2023), the strongest burst keyword was silver nanoparticle, and the strongest burst reference was Whiteley et al. (2017). The co-citation network revealed that the most important interest and research direction was anti-biofilm/anti-virulence drug development, and timeline analysis suggested that this direction is also the most active. The key concepts alluvial flow visualization revealed seven terms with the longest time span and lasting until now, namely Escherichia coli, virulence, Pseudomonas aeruginosa, virulence factor, bacterial biofilm, gene expression, quorum sensing. Comprehensive analysis shows that nanomaterials, marine natural products, and artificial intelligence (AI) may become hotspots in the future.
UNASSIGNED: This bibliometric study reveals the current status and trends of anti-QSA research and may assist researchers in identifying hot topics and exploring new research directions.
摘要：
■群体感应是细菌根据人口密度进行交流和调节其行为的能力。抗群体感应剂（抗QSA）是治疗耐药感染的有希望的策略，以及降低导致临床相关病原体的抗生素耐药性的选择压力。这项研究分析了产出，热点,以及针对临床相关病原体的抗QSA领域的研究趋势。
■检索并分析了来自WebofScienceCoreCollection数据库的有关抗QSA的文献。使用CiteSpace和冲积生成器等工具来可视化和解释数据。
■从1998年到2023年，与反QAS研究有关的出版物数量迅速增加，在558种期刊上发表了1,743篇文章和评论。美国是最大的捐助国和最具影响力的国家，H指数为88，高于其他国家。威廉姆斯是最有成效的作家，霍比·N是被引用次数最多的作者。微生物学前沿是最多产和被引用最多的期刊。突发检测表明，主要的前沿学科从微生物学转向，临床,分子生物学,以及其他与食品相关的生物医学领域，材料,天然产品,和多学科。在整个研究历史中,最强的爆发关键词是囊性纤维化患者，最强的爆发参考是Lee和Zhang(2015)。在最近一段时间(爆发到2023年)，最强爆发关键词是银纳米粒子，最强的爆发参考是Whiteley等人。(2017)。共引网络显示，最重要的兴趣和研究方向是抗生物膜/抗毒力药物的开发，和时间线分析表明，这个方向也是最活跃的。冲积流可视化的关键概念揭示了七个时间跨度最长、持续时间至今的术语，即大肠杆菌，毒力,铜绿假单胞菌,毒力因子，细菌生物膜，基因表达，仲裁感应。综合分析表明,纳米材料,海洋天然产物,人工智能（AI）可能成为未来的热点。
■这项文献计量学研究揭示了反QSA研究的现状和趋势，可能有助于研究人员确定热门话题并探索新的研究方向。
■检索并分析了来自WebofScienceCoreCollection数据库的有关抗QSA的文献。使用CiteSpace和冲积生成器等工具来可视化和解释数据。
■从1998年到2023年，与反QAS研究有关的出版物数量迅速增加，在558种期刊上发表了1,743篇文章和评论。美国是最大的捐助国和最具影响力的国家，H指数为88，高于其他国家。威廉姆斯是最有成效的作家，霍比·N是被引用次数最多的作者。微生物学前沿是最多产和被引用最多的期刊。突发检测表明，主要的前沿学科从微生物学转向，临床,分子生物学,以及其他与食品相关的生物医学领域，材料,天然产品,和多学科。在整个研究历史中,最强的爆发关键词是囊性纤维化患者，最强的爆发参考是Lee和Zhang(2015)。在最近一段时间(爆发到2023年)，最强爆发关键词是银纳米粒子，最强的爆发参考是Whiteley等人。(2017)。共引网络显示，最重要的兴趣和研究方向是抗生物膜/抗毒力药物的开发，和时间线分析表明，这个方向也是最活跃的。冲积流可视化的关键概念揭示了七个时间跨度最长、持续时间至今的术语，即大肠杆菌，毒力,铜绿假单胞菌,毒力因子，细菌生物膜，基因表达，仲裁感应。综合分析表明,纳米材料,海洋天然产物,人工智能（AI）可能成为未来的热点。
■这项文献计量学研究揭示了反QSA研究的现状和趋势，可能有助于研究人员确定热门话题并探索新的研究方向。
