Abstract：
Injuries and damage to the skin can be caused by different reasons throughout human life. The use of sodium alginate in tissue dressing has been highly studied due to its intrinsic properties, including its degradation rate and biocompatibility, and the capacity of supporting tissue proliferation. The aim of this paper is to demonstrate evidences, through a systematic review method, to support the application of sodium alginate as a curative and as a potential accelerator in the healing of skin wounds. Four databases were used to develop this systematic review: Science Direct, PubMed, Scielo and Scopus. The time interval established for the search was from January 2016 to October 2023. After applying the exclusion and inclusion criteria, each selected article was evaluated and it was observed that the improvement of the mechanical properties of sodium alginate when correctly processed and crosslinked were evident. However, the increase of crosslinking affects as the wettability and the swelling of the biomaterials can cause limitations in mechanical properties and hidrophilic behavior. To achieve the ideal dressing, it is necessary to apply the optimal concentration of crosslinking and other substances, which can damage its hidrophilic characteristic. Thus, it was concluded that sodium alginate has every caracteristic desirable to develop an effective and safe dressing.
摘要：
在整个人类生活中，皮肤的损伤和损伤可能由不同的原因引起。海藻酸钠在组织敷料中的使用已被高度研究，由于其固有的性质，包括其降解速率和生物相容性，和支持组织增殖的能力。本文的目的是证明证据，通过系统回顾的方法，支持海藻酸钠作为治疗药物和潜在的加速剂在皮肤伤口愈合中的应用。四个数据库被用来开发这个系统综述：科学直接，PubMed,Scielo和Scopus.为搜索确定的时间间隔为2016年1月至2023年10月。在应用排除和纳入标准后，对每个选定的制品进行评估，观察到当正确处理和交联时，海藻酸钠的机械性能的改善是明显的。然而,交联作用的增加，因为生物材料的润湿性和溶胀会导致机械性能和亲细胞行为的限制。为了获得理想的敷料，有必要应用交联和其他物质的最佳浓度，这可能会损害它的亲细胞特性。因此，结论是海藻酸钠具有开发有效和安全的敷料所需的各种特性。
