PDF(Pubmed)
Abstract：
The beneficial effects of Akkermansia muciniphila (Akk) on gut health and inflammation reduction have been demonstrated; however, scientific evidence of hair growth enhancement by Akk has not been reported. Therefore, this study was undertaken to investigate the effect of Akk on improving testosterone-mediated hair growth inhibition. Hair growth inhibition was induced through subcutaneous injection of testosterone into the shaved dorsal skin of C57BL/6 male mice. Live and pasteurized Akk were orally administered at a concentration of 1 × 108 colony-forming unit. After 5 weeks, hair length and skin tissues were analyzed. The live and pasteurized Akk significantly stimulated hair growth, countering the inhibitory effect of testosterone compared to the testosterone-alone group. Hematoxylin and eosin staining revealed a significant increase in hair follicle size in the Akk-treated group. An increase in β-catenin levels, which are associated with hair growth and cell cycle progression, was also observed. Moreover, the Akk-treated group exhibited increased levels of fibroblast growth factors, including Fgf7, Igf1, Fgf7, Fgf10, and Fgf21. However, no significant difference was observed between the live and pasteurized Akk groups. These results underscore the potential of live and pasteurized Akk in improving testosterone-mediated hair growth inhibition.
摘要：
已证明Akkermansiamuciniphila（Akk）对肠道健康和减少炎症的有益作用；然而，Akk促进头发生长的科学证据尚未报道。因此,本研究旨在研究Akk对改善睾酮介导的毛发生长抑制的作用.通过将睾酮皮下注射到C57BL/6雄性小鼠的剃毛背侧皮肤中来诱导毛发生长抑制。以1×108集落形成单位的浓度口服施用活的和巴氏灭菌的Akk。5周后,头发长度和皮肤组织进行分析。活的和巴氏灭菌的Akk显着刺激头发生长，与单独使用睾丸激素组相比，可以抵消睾丸激素的抑制作用。苏木精和伊红染色显示在Akk治疗组中毛囊大小显著增加。β-连环蛋白水平的增加，它们与毛发生长和细胞周期进程有关，也被观察到了。此外，Akk治疗组显示成纤维细胞生长因子水平升高，包括Fgf7、Igf1、Fgf7、Fgf10和Fgf21。然而,在活的和巴氏灭菌的Akk组之间没有观察到显著差异。这些结果强调了活的和巴氏灭菌的Akk在改善睾酮介导的毛发生长抑制中的潜力。
