Abstract：
OBJECTIVE: This study was designed to comprehensively evaluate the changes in facial skin biophysical parameters with age, as well the influence of gender differences in populations of Shaanxi Province, China.
METHODS: Fourteen skin parameters, including stratum corneum hydration (SCH), transdermal water loss (TEWL), erythema, melanin, R0, R2, R5, R7, F4, gloss, skin surface pH, skin erythema index (a*), wrinkle length, and sebum, were measured by noninvasive instruments in 481 volunteers from Shaanxi Province. Spearman correlation analysis was performed to analyze the relationship between skin parameters and age. Additionally, skin parameters were analyzed for different age groups and different genders.
RESULTS: The results of the study showed a linear decrease in skin surface pH and sebum content with age, and the skin elasticity parameters R0, R2, R5, and R7 decreased significantly at the age of 54-65 years. Wrinkle length showed a linear and increase with age. R5 showed a weak negative correlation with age, R2, R7, and sebum content showed a moderate negative correlation, while wrinkle length showed a strong positive correlation. Considering the effect of gender on skin parameters, the results showed that SCH and gloss were lower in men than in women, while TEWL, erythema, melanin, wrinkle length, and sebum were higher than in women. However, there was no difference in skin elasticity between them.
CONCLUSIONS: The facial skin parameters, especially for the wrinkle length, exhibited the strong correlation relationship with ages in Shaanxi Province. Meanwhile, most skin parameters show significant differences with gender, which can provide a reference for future research and development in the field of cosmetics.
METHODS: Fourteen skin parameters, including stratum corneum hydration (SCH), transdermal water loss (TEWL), erythema, melanin, R0, R2, R5, R7, F4, gloss, skin surface pH, skin erythema index (a*), wrinkle length, and sebum, were measured by noninvasive instruments in 481 volunteers from Shaanxi Province. Spearman correlation analysis was performed to analyze the relationship between skin parameters and age. Additionally, skin parameters were analyzed for different age groups and different genders.
RESULTS: The results of the study showed a linear decrease in skin surface pH and sebum content with age, and the skin elasticity parameters R0, R2, R5, and R7 decreased significantly at the age of 54-65 years. Wrinkle length showed a linear and increase with age. R5 showed a weak negative correlation with age, R2, R7, and sebum content showed a moderate negative correlation, while wrinkle length showed a strong positive correlation. Considering the effect of gender on skin parameters, the results showed that SCH and gloss were lower in men than in women, while TEWL, erythema, melanin, wrinkle length, and sebum were higher than in women. However, there was no difference in skin elasticity between them.
CONCLUSIONS: The facial skin parameters, especially for the wrinkle length, exhibited the strong correlation relationship with ages in Shaanxi Province. Meanwhile, most skin parameters show significant differences with gender, which can provide a reference for future research and development in the field of cosmetics.
摘要：
目的：本研究旨在全面评估面部皮肤生物物理参数随年龄的变化，以及陕西省人口性别差异的影响，中国。
方法：十四个皮肤参数，包括角质层水合作用（SCH），透皮失水(TEWL)，红斑,黑色素,R0，R2，R5，R7，F4，光泽，皮肤表面pH值,皮肤红斑指数（a*），皱纹长度,和皮脂,对陕西省481名志愿者进行了无创仪器测量。采用Spearman相关性分析皮肤参数与年龄的关系。此外,对不同年龄、不同性别的皮肤参数进行分析。
结果：研究结果表明，随着年龄的增长，皮肤表面pH值和皮脂含量呈线性下降，皮肤弹性参数R0、R2、R5和R7在54-65岁时显著降低。皱纹长度呈线性，并随年龄增长而增加。R5与年龄呈弱负相关，R2、R7和皮脂含量呈中度负相关,而皱纹长度表现出较强的正相关性。考虑到性别对皮肤参数的影响，结果表明，男性的SCH和光泽度低于女性，而TEWL,红斑,黑色素,皱纹长度,皮脂高于女性。然而,它们之间的皮肤弹性没有差异。
结论：面部皮肤参数，尤其是皱纹的长度，陕西省人口与年龄呈强相关关系。同时,大多数皮肤参数与性别有显著差异，可为今后化妆品领域的研发提供参考。
方法：十四个皮肤参数，包括角质层水合作用（SCH），透皮失水(TEWL)，红斑,黑色素,R0，R2，R5，R7，F4，光泽，皮肤表面pH值,皮肤红斑指数（a*），皱纹长度,和皮脂,对陕西省481名志愿者进行了无创仪器测量。采用Spearman相关性分析皮肤参数与年龄的关系。此外,对不同年龄、不同性别的皮肤参数进行分析。
结果：研究结果表明，随着年龄的增长，皮肤表面pH值和皮脂含量呈线性下降，皮肤弹性参数R0、R2、R5和R7在54-65岁时显著降低。皱纹长度呈线性，并随年龄增长而增加。R5与年龄呈弱负相关，R2、R7和皮脂含量呈中度负相关,而皱纹长度表现出较强的正相关性。考虑到性别对皮肤参数的影响，结果表明，男性的SCH和光泽度低于女性，而TEWL,红斑,黑色素,皱纹长度,皮脂高于女性。然而,它们之间的皮肤弹性没有差异。
结论：面部皮肤参数，尤其是皱纹的长度，陕西省人口与年龄呈强相关关系。同时,大多数皮肤参数与性别有显著差异，可为今后化妆品领域的研发提供参考。
