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Abstract：
Neurodegenerative diseases seriously affect patients\' physical and mental health, reduce their quality of life, and impose a heavy burden on society. However, their treatment remains challenging. Therefore, exploring factors potentially related to the pathogenesis of neurodegenerative diseases and improving their diagnosis and treatment are urgently needed. Recent studies have shown that P2 × 7R plays a crucial role in regulating neurodegenerative diseases caused by neuroinflammation. P2 × 7R is an adenosine 5\'-triphosphate ligand-gated cation channel receptor present in most tissues of the human body. An increase in P2 × 7R levels can affect the progression of neurodegenerative diseases, and the inhibition of P2 × 7R can alleviate neurodegenerative diseases. In this review, we comprehensively describe the biological characteristics (structure, distribution, and function) of this gene, focusing on its potential association with neurodegenerative diseases, and we discuss the pharmacological effects of drugs (P2 × 7R inhibitors) used to treat neurodegenerative diseases.
摘要：
神经退行性疾病严重影响患者的身心健康,降低他们的生活质量，给社会带来沉重负担。然而,他们的治疗仍然具有挑战性。因此,探索与神经退行性疾病发病机制相关的潜在因素，提高其诊断和治疗水平是迫切需要的。最近的研究表明，P2×7R在调节由神经炎症引起的神经退行性疾病中起着至关重要的作用。P2×7R是存在于人体大多数组织中的腺苷5'-三磷酸配体门控阳离子通道受体。P2×7R水平的升高可以影响神经退行性疾病的进展，抑制P2×7R可以缓解神经退行性疾病。在这次审查中,我们全面描述了生物特征(结构，分布，和功能)的这个基因，关注其与神经退行性疾病的潜在关联，我们讨论了用于治疗神经退行性疾病的药物（P2×7R抑制剂）的药理作用。
