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Abstract：
For decades, most studies of ovarian aging have focused on its functional units, known as follicles, which include oocytes and granulosa cells. However, in the ovarian stroma, there are a variety of somatic components that bridge the gap between general aging and ovarian senescence. Physiologically, general cell types, microvascular structures, extracellular matrix, and intercellular molecules affect folliculogenesis and corpus luteum physiology alongside the ovarian cycle. As a result of damage caused by age-related metabolite accumulation and external insults, the microenvironment of stromal cells is progressively remodeled, thus inevitably perturbing ovarian physiology. With the established platforms for follicle cryopreservation and in vitro maturation and the development of organoid research, it is desirable to develop strategies to improve the microenvironment of the follicle by targeting the perifollicular environment. In this review, we summarize the role of stromal components in ovarian aging, describing their age-related alterations and associated effects. Moreover, we list some potential techniques that may mitigate ovarian aging based on their effect on the stromal microenvironment.
摘要：
几十年来,大多数关于卵巢衰老的研究都集中在其功能单位上，被称为毛囊，其中包括卵母细胞和颗粒细胞。然而,在卵巢基质中，有多种躯体成分在一般衰老和卵巢衰老之间架起了桥梁。生理学上,一般细胞类型，微血管结构,细胞外基质，细胞间分子与卵巢周期一起影响卵泡发生和黄体生理。由于与年龄有关的代谢物积累和外部侮辱造成的损害，基质细胞的微环境逐渐重塑，因此不可避免地扰乱卵巢生理。随着卵泡冷冻保存和体外成熟平台的建立以及类器官研究的发展，通过靶向卵泡周围环境来开发改善卵泡微环境的策略是可取的。在这次审查中,我们总结了基质成分在卵巢衰老中的作用，描述他们与年龄相关的改变和相关影响。此外，根据对基质微环境的影响,我们列出了一些可能减轻卵巢衰老的潜在技术.
