Abstract：
BACKGROUND: Endothelial dysfunction and peak oxygen uptake (VO2peak) are also predictors of increased risk of cardiovascular events in heart transplantation (HTx) recipients. The preservation of endothelial function may contribute to exercise tolerance.
OBJECTIVE: To investigate the correlation between peripheral endothelial function and exercise tolerance through VO2peak and ventilation to carbon dioxide production slope (VE / VCO2 slope) in HTx recipients.
METHODS: A pilot cross-sectional study was conducted with adult individuals aged 18-65 years, HTx ≥ six months after surgery, who had a stable medical condition and no changes over the last three months of immunosuppressive treatment. The patients underwent an assessment of endothelial function through PAT (EndoPAT-2000®) and performed a cardiopulmonary exercise test (CPET).
RESULTS: A total of 41% of the studied population presented endothelial dysfunction. The individuals were divided into two groups: the endothelial dysfunction (GED; n=9) group and the normal endothelial function (GNEF; n=13) group according to the logarithm of the reactive hyperemia index (LnRHI). There was a positive and moderate correlation between the LnRHI and VO2 peak (r=0.659, p=0.013) and a negative and moderate correlation between the LnRHI and VE/VCO2 slope (r= -0.686, p= 0.009) in the GNEF. However, no significant correlations were found in the GED.
CONCLUSIONS: The results showed that the preservation of peripheral endothelial function is significantly correlated with an increase in exercise tolerance in individuals after HTx. These findings bring important considerations for cardiovascular risk prevention and emphasize that therapeutic strategies with physical training programs must be implemented early.
OBJECTIVE: To investigate the correlation between peripheral endothelial function and exercise tolerance through VO2peak and ventilation to carbon dioxide production slope (VE / VCO2 slope) in HTx recipients.
METHODS: A pilot cross-sectional study was conducted with adult individuals aged 18-65 years, HTx ≥ six months after surgery, who had a stable medical condition and no changes over the last three months of immunosuppressive treatment. The patients underwent an assessment of endothelial function through PAT (EndoPAT-2000®) and performed a cardiopulmonary exercise test (CPET).
RESULTS: A total of 41% of the studied population presented endothelial dysfunction. The individuals were divided into two groups: the endothelial dysfunction (GED; n=9) group and the normal endothelial function (GNEF; n=13) group according to the logarithm of the reactive hyperemia index (LnRHI). There was a positive and moderate correlation between the LnRHI and VO2 peak (r=0.659, p=0.013) and a negative and moderate correlation between the LnRHI and VE/VCO2 slope (r= -0.686, p= 0.009) in the GNEF. However, no significant correlations were found in the GED.
CONCLUSIONS: The results showed that the preservation of peripheral endothelial function is significantly correlated with an increase in exercise tolerance in individuals after HTx. These findings bring important considerations for cardiovascular risk prevention and emphasize that therapeutic strategies with physical training programs must be implemented early.
摘要：
背景：内皮功能障碍和峰值摄氧量（VO2peak）也是心脏移植（HTx）受者心血管事件风险增加的预测因子。内皮功能的保留可能有助于运动耐量。
目的：通过VO2peak和通气对HTx受者二氧化碳生成斜率（VE/VCO2斜率）研究外周内皮功能和运动耐量之间的相关性。
方法：对18-65岁的成年人进行了一项试点横断面研究，HTx≥术后6个月，他们的病情稳定，在过去三个月的免疫抑制治疗中没有变化。患者通过PAT（EndoPAT-2000®）评估内皮功能，并进行心肺运动试验（CPET）。
结果：研究人群中有41%表现为内皮功能障碍。根据反应性充血指数（LnRHI）的对数将个体分为两组：内皮功能障碍（GED；n=9）组和内皮功能正常（GNEF；n=13）组。GNEF中LnRHI和VO2峰值之间存在正相关和中度相关（r=0.659，p=0.013），LnRHI和VE/VCO2斜率之间存在负相关和中度相关（r=-0.686，p=0.009）。然而,在GED中没有发现显著的相关性.
结论：结果显示，HTx后个体外周内皮功能的保持与运动耐量的增加显著相关。这些发现为预防心血管风险带来了重要的考虑因素，并强调必须尽早实施体育锻炼计划的治疗策略。
目的：通过VO2peak和通气对HTx受者二氧化碳生成斜率（VE/VCO2斜率）研究外周内皮功能和运动耐量之间的相关性。
方法：对18-65岁的成年人进行了一项试点横断面研究，HTx≥术后6个月，他们的病情稳定，在过去三个月的免疫抑制治疗中没有变化。患者通过PAT（EndoPAT-2000®）评估内皮功能，并进行心肺运动试验（CPET）。
结果：研究人群中有41%表现为内皮功能障碍。根据反应性充血指数（LnRHI）的对数将个体分为两组：内皮功能障碍（GED；n=9）组和内皮功能正常（GNEF；n=13）组。GNEF中LnRHI和VO2峰值之间存在正相关和中度相关（r=0.659，p=0.013），LnRHI和VE/VCO2斜率之间存在负相关和中度相关（r=-0.686，p=0.009）。然而,在GED中没有发现显著的相关性.
结论：结果显示，HTx后个体外周内皮功能的保持与运动耐量的增加显著相关。这些发现为预防心血管风险带来了重要的考虑因素，并强调必须尽早实施体育锻炼计划的治疗策略。
