Abstract：
Cancer patients are often diagnosed with venous thromboembolism (VTE), a cardiovascular disease that substantially decreases their quality of life and survival rate. Haemostasis in these patients is deregulated, which is reflected in the common presentation of a blood hypercoagulation state. Despite the inconsistent results, existing evidence suggests that the expression of microRNAs (miRNAs) is deregulated in the context of venous thrombogenesis in the general population. However, few miRNAs are known to be linked to cancer-associated VTE due to the lack of studies with oncological patients. Parallelly, coagulation factor III, also known as tissue factor (TF), tissue factor pathway inhibitor 1 (TFPI1) and tissue factor pathway inhibitor 2 (TFPI2) have been proposed to have a central role in cancer-associated VTE and tumour progression. Yet, contrary to what was expected, the role of miRNAs targeting the TF coagulation pathway (or extrinsic coagulation pathway) is poorly explored in cancer-induced thrombogenesis. In this review, in addition to miRNAs implicated in VTE, TF and TFPI1/2-targeting miRNAs were revised. Future studies should clarify the implications of these non-coding RNAs in tumour coagulome.
摘要：
癌症患者通常被诊断为静脉血栓栓塞症（VTE），严重降低其生活质量和生存率的心血管疾病。这些患者的止血失调，这反映在血液高凝状态的常见表现中。尽管结果不一致，现有证据表明,在普通人群中,在静脉血栓形成的背景下,microRNAs(miRNAs)的表达是失调的.然而,由于缺乏对肿瘤患者的研究,已知很少miRNA与癌症相关的VTE相关.同样，凝血因子III,也称为组织因子（TF），组织因子途径抑制因子1(TFPI1)和组织因子途径抑制因子2(TFPI2)已被认为在癌症相关的VTE和肿瘤进展中具有重要作用.然而，与预期相反，靶向TF凝血途径(或外源性凝血途径)的miRNA在癌症诱导的血栓形成中的作用研究甚少。在这次审查中,除了与VTE有关的miRNA，修订了TF和TFPI1/2靶向miRNA。未来的研究应该阐明这些非编码RNA在肿瘤凝固组中的意义。
