Abstract：
Ketogenic diets (KD) have been used in the treatment of epilepsy in humans for around a century and, more recently, they have been implanted for cancer patients, as well as in the treatment of obesity. This type of diet consists of high-fat levels, an adequate amount of protein and restricted carbohydrates, or high medium-chain triglycerides. Recently, the ketogenic diet has gained attention in veterinary medicine and studies were published evaluating the effects of KD in dogs with epilepsy. The objective of this review was to highlight recent studies about the application of KD in dogs and cats, to describe the neurobiochemical mechanisms through which KD improves epilepsy crisis, and their adverse effects. Studies were identified by a systematic review of literature available on PubMed, Embase, and Scopus. All cohort and case-control studies were included, and all articles were exported to Mendeley® citation manager, and duplicates were automatically removed. Seven articles and three conference abstracts conducted with dogs were included in the present study. There is evidence that the consumption of diets with medium-chain triglycerides increases the concentration of circulating ketone bodies and improves epilepsy signs, although these diets have higher carbohydrate and lower fat content when compared to the classic KD.
摘要：
生酮饮食(KD)已经用于治疗人类癫痫大约一个世纪,最近,它们已经被植入癌症患者，以及肥胖的治疗。这种类型的饮食包括高脂肪水平，足量的蛋白质和限制的碳水化合物，或高中链甘油三酯。最近,生酮饮食在兽医学中引起了人们的关注，并且发表了评估KD对癫痫犬的影响的研究。这篇综述的目的是强调最近关于KD在狗和猫中应用的研究，来描述KD改善癫痫危机的神经生化机制，以及它们的不利影响。通过对PubMed上现有文献的系统回顾来确定研究，Embase,还有Scopus.纳入所有队列和病例对照研究，所有文章都出口到Mendeley®引文管理器，和重复项被自动删除。本研究包括七篇文章和三篇关于狗的会议摘要。有证据表明，食用含有中链甘油三酯的饮食会增加循环酮体的浓度并改善癫痫症状，尽管与经典KD相比，这些饮食具有更高的碳水化合物和更低的脂肪含量。
