PDF(Pubmed)
Abstract：
Background: An increasing number of studies have suggested the relationship between single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes and gastric cancer (GC) susceptibility; however, the available evidence is contradictory. This meta-analysis aimed to comprehensively evaluate whether the SNPs within the TLR family are related to GC development. Methods: PubMed, Scopus, and China National Knowledge Infrastructure (CNKI) were systematically searched up to May 2023 to obtain the pertinent publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were applied to examine the associations using the random-effects model. Results: A total of 45 studies with 25,831 participants (cases: 11,308; controls: 14,523) examining the relation of 18 different SNPs in the TLR family to GC were analyzed. Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models. No significant association was detected for TLR-2-196 to -174de (Delta22), TLR-2 rs3804100, TLR-4 rs11536889, TLR-4 rs11536878, TLR-4 rs2770150, TLR-4 rs10116253, TLR-4 rs1927911, TLR-4 rs10983755, TLR-4 rs10759932, TLR-4 rs1927914, and TLR-10 rs10004195. Conclusion: These findings indicate that variations in TLR-4, TLR-5, and TLR-9 genes were found to be potential risk factors for GC.
摘要：
背景:越来越多的研究表明Toll样受体(TLR)基因中的单核苷酸多态性(SNPs)与胃癌(GC)易感性之间的关系;然而,现有的证据是矛盾的。本荟萃分析旨在全面评估TLR家族中的SNP是否与GC发生有关。方法:PubMed,Scopus,到2023年5月，对中国国家知识基础设施(CNKI)进行了系统搜索，获得了相关出版物。使用随机效应模型，将具有95％置信区间（CI）的汇总优势比（OR）用于检查关联。结果：共分析了45项研究，其中25,831名参与者（病例：11,308；对照：14,523），检查了TLR家族中18种不同SNP与GC的关系。在不同的遗传模型中，TLR-4rs4986790，TLR-4rs4986791，TLR-5rs5744174和TLR-9rs187084的变异与GC风险增加显着相关。TLR-2-196与-174de(Delta22)没有检测到显著关联，TLR-2rs3804100、TLR-4rs11536889、TLR-4rs11536878、TLR-4rs2770150、TLR-4rs10116253、TLR-4rs1927911、TLR-4rs10983755、TLR-4rs10759932、TLR-4rs1927914和TLR-10。结论：这些发现表明TLR-4，TLR-5和TLR-9基因的变异被发现是GC的潜在危险因素。
