PDF(Pubmed)
Abstract：
UNASSIGNED: COVID-19 increases the risk of cardiovascular disease, especially thrombotic complications. There is less knowledge on the risk of arrhythmias after COVID-19. In this study, we aimed to quantify the risk of arrhythmias following COVID-19.
UNASSIGNED: This study was based on national register data on all individuals in Sweden who tested positive for SARS-CoV-2 between 1 February 2020 and 25 May 2021. The outcome was incident cardiac arrhythmias, defined as international classification of diseases (10th revision) codes in the registers as follows: atrial arrhythmias; paroxysmal supraventricular tachycardias; bradyarrhythmias; and ventricular arrhythmias. A self-controlled case series study and a matched cohort study, using conditional Poisson regression, were performed to determine the incidence rate ratio and risk ratio, respectively, for an arrhythmia event following COVID-19.A total of 1 057 174 exposed (COVID-19) individuals were included in the study as well as 4 074 844 matched unexposed individuals. The incidence rate ratio of atrial tachycardias, paroxysmal supraventricular tachycardias, and bradyarrhythmias was significantly increased up to 60, 180, and 14 days after COVID-19, respectively. In the matched cohort study, the risk ratio during Days 1-30 following COVID-19/index date was 12.28 (10.79-13.96), 5.26 (3.74-7.42), and 3.36 (2.42-4.68), respectively, for the three outcomes. The risks were generally higher in older individuals, in unvaccinated individuals, and in individuals with more severe COVID-19. The risk of ventricular arrhythmias was not increased.
UNASSIGNED: There is an increased risk of cardiac arrhythmias following COVID-19, and particularly increased in elderly vulnerable individuals, as well as in individuals with severe COVID-19.
UNASSIGNED: This study was based on national register data on all individuals in Sweden who tested positive for SARS-CoV-2 between 1 February 2020 and 25 May 2021. The outcome was incident cardiac arrhythmias, defined as international classification of diseases (10th revision) codes in the registers as follows: atrial arrhythmias; paroxysmal supraventricular tachycardias; bradyarrhythmias; and ventricular arrhythmias. A self-controlled case series study and a matched cohort study, using conditional Poisson regression, were performed to determine the incidence rate ratio and risk ratio, respectively, for an arrhythmia event following COVID-19.A total of 1 057 174 exposed (COVID-19) individuals were included in the study as well as 4 074 844 matched unexposed individuals. The incidence rate ratio of atrial tachycardias, paroxysmal supraventricular tachycardias, and bradyarrhythmias was significantly increased up to 60, 180, and 14 days after COVID-19, respectively. In the matched cohort study, the risk ratio during Days 1-30 following COVID-19/index date was 12.28 (10.79-13.96), 5.26 (3.74-7.42), and 3.36 (2.42-4.68), respectively, for the three outcomes. The risks were generally higher in older individuals, in unvaccinated individuals, and in individuals with more severe COVID-19. The risk of ventricular arrhythmias was not increased.
UNASSIGNED: There is an increased risk of cardiac arrhythmias following COVID-19, and particularly increased in elderly vulnerable individuals, as well as in individuals with severe COVID-19.
摘要：
■COVID-19增加心血管疾病的风险，尤其是血栓性并发症.对COVID-19后心律失常风险的了解较少。在这项研究中,我们旨在量化COVID-19后心律失常的风险。
这项研究基于瑞典所有在2020年2月1日至2021年5月25日期间检测出SARS-CoV-2阳性的个人的国家登记数据。结果是偶发心律失常，在登记册中定义为国际疾病分类(第10次修订)代码如下:房性心律失常;阵发性室上性心动过速;缓慢性心律失常;和室性心律失常。自我对照病例系列研究和配对队列研究，使用条件泊松回归，进行以确定发病率比率和风险比率，分别,COVID-19后的心律失常事件。该研究共纳入1057174名暴露(COVID-19)个体，以及4074844名匹配的未暴露个体。房性心动过速的发生率，阵发性室上性心动过速,和缓慢性心律失常分别在COVID-19后60、180和14天显著增加。在配对的队列研究中，COVID-19/指数日期后第1-30天的风险比为12.28（10.79-13.96），5.26(3.74-7.42),和3.36（2.42-4.68），分别,这三个结果。老年人的风险普遍较高，在未接种疫苗的个体中，以及患有更严重的COVID-19的个体。室性心律失常的风险没有增加。
COVID-19后发生心律失常的风险增加，尤其是在老年脆弱人群中，以及患有严重COVID-19的个体。
这项研究基于瑞典所有在2020年2月1日至2021年5月25日期间检测出SARS-CoV-2阳性的个人的国家登记数据。结果是偶发心律失常，在登记册中定义为国际疾病分类(第10次修订)代码如下:房性心律失常;阵发性室上性心动过速;缓慢性心律失常;和室性心律失常。自我对照病例系列研究和配对队列研究，使用条件泊松回归，进行以确定发病率比率和风险比率，分别,COVID-19后的心律失常事件。该研究共纳入1057174名暴露(COVID-19)个体，以及4074844名匹配的未暴露个体。房性心动过速的发生率，阵发性室上性心动过速,和缓慢性心律失常分别在COVID-19后60、180和14天显著增加。在配对的队列研究中，COVID-19/指数日期后第1-30天的风险比为12.28（10.79-13.96），5.26(3.74-7.42),和3.36（2.42-4.68），分别,这三个结果。老年人的风险普遍较高，在未接种疫苗的个体中，以及患有更严重的COVID-19的个体。室性心律失常的风险没有增加。
COVID-19后发生心律失常的风险增加，尤其是在老年脆弱人群中，以及患有严重COVID-19的个体。
