Abstract：
Hydrofluoric acid (HF) is a ubiquitous industrial chemical that is particularly hazardous because of the potential for systemic effects and the induction of severe cutaneous necrosis after contact with the skin. Minimizing skin injury requires decontaminating the affected area promptly with an emergency rinsing solution. Few experimental studies have objectively characterized rinsing solutions such as Diphoterine (DP). Here we develop an ex vivo pigskin model to study and compare the efficacy of rinsing solutions as initial decontaminating agents to stop the progression of skin lesions after HF splashing. The pigskin model shows an immediate local response to HF at varying concentrations and exposure times. We then exposed the pigskin biopsies to 3.75% HF for 1 min and rinsed them with different solutions, including water, 0.9% NaCl solution (saline), 10% calcium gluconate (CaG), Hexafluorine (HXF), and DP. We found DP to be a more effective agent for decontaminating HF lesions than water, saline, and CaG. DP had a similar efficacy as HXF, an emergency rinsing solution used specifically for decontaminating HF-exposed skin. This study shows that skin exposed to HF must be treated quickly from the first minute of exposure.
摘要：
氢氟酸（HF）是一种普遍存在的工业化学品，由于与皮肤接触后可能引起全身作用和严重的皮肤坏死，因此特别危险。最小化皮肤损伤需要用紧急冲洗溶液迅速净化受影响的区域。很少有实验研究客观地表征了冲洗溶液，例如Diphonterine（DP）。在这里，我们开发了一种离体猪皮模型，以研究和比较冲洗溶液作为初始去污剂的功效，以阻止HF飞溅后皮肤病变的进展。猪皮模型显示在不同浓度和暴露时间对HF的即时局部反应。然后，我们将猪皮活检暴露于3.75％HF1分钟，并用不同的溶液冲洗它们，包括水,0.9%NaCl溶液（盐水），10%葡萄糖酸钙(CaG),六氟（HXF），和DP。我们发现DP是一种比水更有效的净化HF病变的药物，盐水,还有CaG.DP的疗效与HXF相似，一种专门用于净化暴露于HF的皮肤的紧急冲洗溶液。这项研究表明，暴露于HF的皮肤必须从暴露的第一分钟开始迅速治疗。
