Abstract：
BACKGROUND: Vitiligo can be challenging to treat and exhibit an unpredictable clinical course. Phototherapy in the form of visible light can achieve both repigmentation and depigmentation outcomes in vitiligo, with minimal associated adverse events. This review focuses on the mechanistic understandings and clinical outcomes of visible light-based treatments for vitiligo.
METHODS: Articles were retrieved from PubMed starting from May 1965 until August 2023, yielding 496 unique articles. We conducted title, abstract, and full-text screening to identify articles describing the use of visible light (380-750 nm), either as part of combination therapy or as monotherapy, for repigmentation or depigmentation treatment in vitiligo.
RESULTS: Twenty-seven articles met inclusion criteria, offering preclinical and clinical data regarding the utilization of helium-neon laser (red light) and blue light-emitting diodes (LEDs) as methods of repigmentation therapy in vitiligo. Preclinical and clinical data on the utilization of Q-switched ruby laser (694 nm) and frequency-doubled (FD) Nd:YAG laser (532 nm) for vitiligo depigmentation therapy were also identified.
CONCLUSIONS: While limited by small studies and a lack of standardized administration of phototherapy, the evidence for visible light\'s effectiveness in managing vitiligo is encouraging. Red light therapy using He-Ne lasers and blue light therapy via LEDs can stimulate repigmentation in patients with vitiligo with minimal adverse events. Q-switched ruby and FD Nd:YAG lasers provide viable, visible light depigmentation options, either alone or with topical agents. With limited clinical data, larger studies are needed to validate the efficacy of visible light therapy in treating vitiligo and to better understand its long-term outcomes.
METHODS: Articles were retrieved from PubMed starting from May 1965 until August 2023, yielding 496 unique articles. We conducted title, abstract, and full-text screening to identify articles describing the use of visible light (380-750 nm), either as part of combination therapy or as monotherapy, for repigmentation or depigmentation treatment in vitiligo.
RESULTS: Twenty-seven articles met inclusion criteria, offering preclinical and clinical data regarding the utilization of helium-neon laser (red light) and blue light-emitting diodes (LEDs) as methods of repigmentation therapy in vitiligo. Preclinical and clinical data on the utilization of Q-switched ruby laser (694 nm) and frequency-doubled (FD) Nd:YAG laser (532 nm) for vitiligo depigmentation therapy were also identified.
CONCLUSIONS: While limited by small studies and a lack of standardized administration of phototherapy, the evidence for visible light\'s effectiveness in managing vitiligo is encouraging. Red light therapy using He-Ne lasers and blue light therapy via LEDs can stimulate repigmentation in patients with vitiligo with minimal adverse events. Q-switched ruby and FD Nd:YAG lasers provide viable, visible light depigmentation options, either alone or with topical agents. With limited clinical data, larger studies are needed to validate the efficacy of visible light therapy in treating vitiligo and to better understand its long-term outcomes.
摘要：
背景：白癜风治疗可能具有挑战性，并表现出不可预测的临床过程。可见光形式的光疗可以在白癜风中实现色素沉着和色素脱失的结果，与最小的相关不良事件。这篇综述的重点是基于可见光的白癜风治疗的机理理解和临床结果。
方法：从1965年5月至2023年8月从PubMed检索文章，产生496篇独特文章。我们进行了标题，abstract,和全文筛选，以识别描述可见光（380-750nm）使用的文章，作为联合治疗的一部分或作为单一治疗，用于白癜风的色素沉着或脱色治疗。
结果：27篇文章符合纳入标准，提供关于利用氦-氖激光（红光）和蓝色发光二极管（LED）作为白癜风色素沉着治疗方法的临床前和临床数据。还确定了使用调Q红宝石激光（694nm）和倍频（FD）Nd：YAG激光（532nm）进行白癜风脱色治疗的临床前和临床数据。
结论：虽然受到小型研究和缺乏标准化光疗管理的限制，可见光治疗白癜风的有效性的证据令人鼓舞。使用He-Ne激光的红光疗法和通过LED的蓝光疗法可以刺激白癜风患者的色素沉着，不良事件最少。调Q红宝石和FDNd:YAG激光器提供可行的，可见光脱色选项，单独或与外用药物。在临床数据有限的情况下，需要更大规模的研究来验证可见光疗法治疗白癜风的疗效,并更好地了解其长期结局.
方法：从1965年5月至2023年8月从PubMed检索文章，产生496篇独特文章。我们进行了标题，abstract,和全文筛选，以识别描述可见光（380-750nm）使用的文章，作为联合治疗的一部分或作为单一治疗，用于白癜风的色素沉着或脱色治疗。
结果：27篇文章符合纳入标准，提供关于利用氦-氖激光（红光）和蓝色发光二极管（LED）作为白癜风色素沉着治疗方法的临床前和临床数据。还确定了使用调Q红宝石激光（694nm）和倍频（FD）Nd：YAG激光（532nm）进行白癜风脱色治疗的临床前和临床数据。
结论：虽然受到小型研究和缺乏标准化光疗管理的限制，可见光治疗白癜风的有效性的证据令人鼓舞。使用He-Ne激光的红光疗法和通过LED的蓝光疗法可以刺激白癜风患者的色素沉着，不良事件最少。调Q红宝石和FDNd:YAG激光器提供可行的，可见光脱色选项，单独或与外用药物。在临床数据有限的情况下，需要更大规模的研究来验证可见光疗法治疗白癜风的疗效,并更好地了解其长期结局.
