Abstract：
An implicit tenet of the alcohol use disorder (AUD) research field is that knowledge of how alcohol interacts with the brain is critical to the development of an understanding of vulnerability to AUD and treatment approaches. Gaining this understanding requires the mapping of brain function critical to specific components of this heterogeneous disorder. Early approaches in humans and animal models focused on the determination of specific brain regions sensitive to alcohol action and their participation in AUD-relevant behaviors. Broadly speaking, this research has focused on three domains, Binge/Intoxication, Negative Affect/Withdrawal, and Preoccupation/Anticipation, with a number of regions identified as participating in each. With the generational advances in technologies that the field of neuroscience has undergone over the last two decades, this focus has shifted to a circuit-based analysis. A wealth of new data has sharpened the field\'s focus on the specific roles of the interconnectivity of multiple brain regions in AUD and AUD-relevant behaviors, as well as demonstrating that the three major domains described above have much fuzzier edges than originally thought.In this chapter, we very briefly review brain regions previously implicated in aspects of AUD-relevant behavior from animal model research. Next, we move to a more in-depth overview of circuit-based approaches, and the utilization of these approaches in current AUD research.
摘要：
酒精使用障碍（AUD）研究领域的隐含原则是，了解酒精如何与大脑相互作用对于理解AUD和治疗方法的脆弱性至关重要。获得这种理解需要绘制对这种异质性疾病的特定成分至关重要的大脑功能。人类和动物模型的早期方法集中于确定对酒精作用敏感的特定大脑区域及其参与AUD相关行为。广义地说,这项研究集中在三个领域，暴饮暴食/中毒，负面影响/撤回，和专注/预期，每个地区都有一些地区参与。随着神经科学领域在过去二十年中经历的技术的代代相传，这个重点已经转移到基于电路的分析。大量的新数据加强了该领域对AUD和AUD相关行为中多个大脑区域互连的特定作用的关注，以及证明上述三个主要领域的边缘比最初想象的要模糊得多。在这一章中,我们从动物模型研究中简要回顾了先前涉及AUD相关行为方面的大脑区域.接下来,我们将对基于电路的方法进行更深入的概述，以及这些方法在当前AUD研究中的应用。
