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Abstract：
OBJECTIVE: The objective of this study was to determine the association between the presence of a microorganism resistant to the antibiotic used in empirical therapy and the development of intra-abdominal abscesses in children with perforated appendicitis.
METHODS: A prospective cohort study was conducted in patients under 18 years of age who underwent laparoscopic appendectomy between November 1, 2019, and September 30, 2020, in whom perforated appendicitis was documented intraoperatively. Peritoneal fluid samples were taken for bacteria culture purposes, and clinical and microbiological data were collected from all patients.
RESULTS: A total of 232 patients were included in the study. The most isolated microorganisms were Escherichia coli (80.14%) and Pseudomonas aeruginosa (7.45%). In addition, 5.31% of E. coli isolates were classified as ESBL-producing organisms. No association was found between a germ resistant to empiric antimicrobial therapy and the development of a postoperative intra-abdominal abscess. Multivariate analysis showed that being a high-risk patient on admission (OR 2.89 (p = 0.01)) was associated with the development of intra-abdominal abscesses postoperatively.
CONCLUSIONS: E. coli was the most commonly isolated microorganism, with a low rate of ESBL-producing isolates. No association between resistance and risk of postoperative intra-abdominal abscess was found. However, it was identified that being a high-risk patient on admission was associated with this complication.
METHODS: Prognosis study.
METHODS: Level I.
METHODS: A prospective cohort study was conducted in patients under 18 years of age who underwent laparoscopic appendectomy between November 1, 2019, and September 30, 2020, in whom perforated appendicitis was documented intraoperatively. Peritoneal fluid samples were taken for bacteria culture purposes, and clinical and microbiological data were collected from all patients.
RESULTS: A total of 232 patients were included in the study. The most isolated microorganisms were Escherichia coli (80.14%) and Pseudomonas aeruginosa (7.45%). In addition, 5.31% of E. coli isolates were classified as ESBL-producing organisms. No association was found between a germ resistant to empiric antimicrobial therapy and the development of a postoperative intra-abdominal abscess. Multivariate analysis showed that being a high-risk patient on admission (OR 2.89 (p = 0.01)) was associated with the development of intra-abdominal abscesses postoperatively.
CONCLUSIONS: E. coli was the most commonly isolated microorganism, with a low rate of ESBL-producing isolates. No association between resistance and risk of postoperative intra-abdominal abscess was found. However, it was identified that being a high-risk patient on admission was associated with this complication.
METHODS: Prognosis study.
METHODS: Level I.
摘要：
目的：本研究的目的是确定对经验性治疗中使用的抗生素耐药的微生物的存在与穿孔性阑尾炎患儿腹内脓肿发展之间的关系。
方法：在2019年11月1日至2020年9月30日期间接受腹腔镜阑尾切除术的18岁以下患者中进行了一项前瞻性队列研究，其中术中记录了穿孔性阑尾炎。采集腹膜液样本用于细菌培养，收集所有患者的临床和微生物学数据.
结果：共有232名患者被纳入研究。分离最多的微生物是大肠杆菌(80.14%)和铜绿假单胞菌(7.45%)。此外,5.31%的大肠杆菌分离株被分类为产生ESBL的生物。对经验性抗微生物疗法耐药的细菌与术后腹内脓肿的发展之间未发现关联。多因素分析表明，入院时的高危患者（OR2.89（p=0.01））与术后腹腔脓肿的发展有关。
结论：E.大肠杆菌是最常见的微生物，产ESBL的分离株率较低。没有发现抵抗与术后腹内脓肿风险之间的关联。然而,研究发现,入院时高危患者与该并发症相关.
方法：预后研究。
方法：一级
方法：在2019年11月1日至2020年9月30日期间接受腹腔镜阑尾切除术的18岁以下患者中进行了一项前瞻性队列研究，其中术中记录了穿孔性阑尾炎。采集腹膜液样本用于细菌培养，收集所有患者的临床和微生物学数据.
结果：共有232名患者被纳入研究。分离最多的微生物是大肠杆菌(80.14%)和铜绿假单胞菌(7.45%)。此外,5.31%的大肠杆菌分离株被分类为产生ESBL的生物。对经验性抗微生物疗法耐药的细菌与术后腹内脓肿的发展之间未发现关联。多因素分析表明，入院时的高危患者（OR2.89（p=0.01））与术后腹腔脓肿的发展有关。
结论：E.大肠杆菌是最常见的微生物，产ESBL的分离株率较低。没有发现抵抗与术后腹内脓肿风险之间的关联。然而,研究发现,入院时高危患者与该并发症相关.
方法：预后研究。
方法：一级
