Abstract：
Lactic acid bacteria (LAB) plays a crucial role in the establishment and maintenance of host health, as well as the improvement of some diseases. One of the major modes is the secretion of metabolites that may be intermediate or end products of the LAB\'s metabolism. In this review, we summarized some common metabolites (particularly short-chain fatty acids [SCFAs], bacteriocin, and exopolysaccharide [EPS]) from LAB in fermented foods and the gut for the first time. The effects of LAB-derived metabolites (LABM) on inflammation, oxidative stress, the intestinal barrier, and gut microbiota in inflammatory bowel disease (IBD) model are also discussed. The discovery of LABM and identification of IBD biomarkers are mainly attributed to the development of metabolomics technologies, especially nuclear magnetic resonance (NMR), gas chromatography-mass spectrometry (GC-MS), and liquid chromatography tandem mass spectrometry (LC-MS). The application of these metabolomics technologies in identification of LABM and IBD biomarkers are also summarized and analyzed. Although the beneficial effects of some LABM have been explored, undiscovered metabolites and their functions still need further investigations.
摘要：
乳酸菌（LAB）在建立和维持宿主健康中起着至关重要的作用，以及一些疾病的改善。其中一个主要模式是代谢产物的分泌,其可能是LAB代谢的中间产物或终产物。在这次审查中,我们总结了一些常见的代谢物(特别是短链脂肪酸[SCFA]，细菌素,和外多糖[EPS]）首次来自发酵食品和肠道中的LAB。LAB衍生的代谢物（LABM）对炎症的影响，氧化应激，肠道屏障,还讨论了炎症性肠病（IBD）模型中的肠道菌群。LABM的发现和IBD生物标志物的鉴定主要归功于代谢组学技术的发展。尤其是核磁共振(NMR),气相色谱-质谱(GC-MS),和液相色谱串联质谱(LC-MS)。对这些代谢组学技术在LABM和IBD生物标志物鉴定中的应用进行了总结和分析。尽管已经探索了一些LABM的有益效果，未发现的代谢物及其功能仍需进一步研究。
