PDF(Pubmed)
Abstract：
UNASSIGNED: Ischemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25-49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990-2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development.
UNASSIGNED: Data from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.
UNASSIGNED: According to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940-21,254,746), 597,137 (548,250-647,778), and 28,692,968 (26,397,448-31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = -0.4%, 95% CI (-0.7% to -0.1%)] and DALYs rate [AAPC = -0.3%, 95% CI (-0.6% to -0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%-0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%-0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from -56.6 [95% CI (-480.4-370.2)] in 1990 to -583.0 [95% CI (-996.8 to -169.2)] in 2019, and the concentration index moved from -8.2 [95% CI (-8.5 to -7.9)] in 1990 to -13.2 [95% CI (-13.9 to -12.4)] in 2019.
UNASSIGNED: While the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.
UNASSIGNED: Data from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries.
UNASSIGNED: According to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940-21,254,746), 597,137 (548,250-647,778), and 28,692,968 (26,397,448-31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = -0.4%, 95% CI (-0.7% to -0.1%)] and DALYs rate [AAPC = -0.3%, 95% CI (-0.6% to -0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%-0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%-0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from -56.6 [95% CI (-480.4-370.2)] in 1990 to -583.0 [95% CI (-996.8 to -169.2)] in 2019, and the concentration index moved from -8.2 [95% CI (-8.5 to -7.9)] in 1990 to -13.2 [95% CI (-13.9 to -12.4)] in 2019.
UNASSIGNED: While the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.
摘要：
■缺血性心脏病（IHD）是全球主要的健康问题，在25-49岁的年轻人中，其负担仍未得到充分开发。这项研究旨在对过去30年（1990-2019年）该年龄组的全球IHD负担和趋势进行全面评估。以及分析与社会经济发展相关的健康不平等。
■来自2019年全球疾病负担研究(GBD2019)的数据被用来分析患病率，死亡率,全球年轻人中IHD的残疾调整寿命年(DALYs)率。Joinpoint回归分析用于检查研究期间的趋势。进行了健康不平等分析，以调查与国家社会人口指数（SDI）相关的IHD负担差异。
■根据GBD2019数据，2019年，全球患有IHD病例的年轻人数量，死亡,和DALYs为18,050,671(95%UI，15,551,940-21,254,746)，597,137（548,250-647,778），和28,692,968（26,397,448-31,178,464），分别,占9.15%，6.53%，占全球病例总数的15.7%。在过去的30年里,死亡率[AAPC=-0.4%，95%CI(-0.7%至-0.1%)]和DALYs比率[AAPC=-0.3%，年轻人IHD的95%CI(-0.6%至-0.1%)]下降，而患病率[AAPC=0.4%，95%CI（0.4%-0.4%）]和YLDs率[AAPC=0.4%，95%CI(0.3%-0.4%)]增加。此外，社会人口指数(SDI)水平较低的国家在年轻人中承担了更高的IHD负担。年轻成人IHD的不平等斜率指数从1990年的-56.6[95％CI（-480.4-370.2）]变为2019年的-583.0[95％CI（-996.8至-169.2）]，浓度指数从1990年的-8.2[95％CI（-8.5至-7.9）]变为2019年的-13.2[95％CI（-13.9至-12.4）]]。
虽然过去30年来全球年轻人的IHD死亡率和DALYs率有所下降，各国与SDI相关的不平等程度继续增加。各国的决策者应明智地分配资源，并实施有效的战略，以改善全球年轻成人IHD的负担，并解决与之相关的健康不平等问题。
■来自2019年全球疾病负担研究(GBD2019)的数据被用来分析患病率，死亡率,全球年轻人中IHD的残疾调整寿命年(DALYs)率。Joinpoint回归分析用于检查研究期间的趋势。进行了健康不平等分析，以调查与国家社会人口指数（SDI）相关的IHD负担差异。
■根据GBD2019数据，2019年，全球患有IHD病例的年轻人数量，死亡,和DALYs为18,050,671(95%UI，15,551,940-21,254,746)，597,137（548,250-647,778），和28,692,968（26,397,448-31,178,464），分别,占9.15%，6.53%，占全球病例总数的15.7%。在过去的30年里,死亡率[AAPC=-0.4%，95%CI(-0.7%至-0.1%)]和DALYs比率[AAPC=-0.3%，年轻人IHD的95%CI(-0.6%至-0.1%)]下降，而患病率[AAPC=0.4%，95%CI（0.4%-0.4%）]和YLDs率[AAPC=0.4%，95%CI(0.3%-0.4%)]增加。此外，社会人口指数(SDI)水平较低的国家在年轻人中承担了更高的IHD负担。年轻成人IHD的不平等斜率指数从1990年的-56.6[95％CI（-480.4-370.2）]变为2019年的-583.0[95％CI（-996.8至-169.2）]，浓度指数从1990年的-8.2[95％CI（-8.5至-7.9）]变为2019年的-13.2[95％CI（-13.9至-12.4）]]。
虽然过去30年来全球年轻人的IHD死亡率和DALYs率有所下降，各国与SDI相关的不平等程度继续增加。各国的决策者应明智地分配资源，并实施有效的战略，以改善全球年轻成人IHD的负担，并解决与之相关的健康不平等问题。
